A rare case of extensive leptomeningitis in neurosarcoidosis.

BMJ Case Rep

Department of Neurology, Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, India.

Published: October 2012

Sarcoidosis is a systemic disease characterised by non-caseating granulomas affecting mainly the lung and lymphatics. Literature reveals that 5% of the patients of sarcoidosis have involvement of the nervous system. Various neurological complications of sarcoidosis commonly reported are cranial nerve palsies, aseptic meningitis, myelopathy and intracranial masses. We report unusual case of neurosarcoidosis who presented with combination of right-sided vision loss and complete ophthalmoplegia with extensive leptomeningitis. This patient was suffering from resistant diabetes which leads to therapeutic problems.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543849PMC
http://dx.doi.org/10.1136/bcr-2012-007090DOI Listing

Publication Analysis

Top Keywords

extensive leptomeningitis
8
rare case
4
case extensive
4
leptomeningitis neurosarcoidosis
4
neurosarcoidosis sarcoidosis
4
sarcoidosis systemic
4
systemic disease
4
disease characterised
4
characterised non-caseating
4
non-caseating granulomas
4

Similar Publications

Context: This study aimed to investigate the characteristics, diagnosis, and management of tuberculous longitudinally extensive transverse myelitis (TB-LETM), a rare manifestation of tuberculosis.

Findings: We analyzed two rare cases of TB-LETM and discussed their clinical manifestations and imaging findings in the context of the relevant literature. Patient 1, a 23-year-old female, presented with quadriplegia and dysuria, and spinal magnetic resonance imaging (MRI) revealed lesions extending from C1 to T3.

View Article and Find Full Text PDF

Introduction: Leptomeningeal disease (LMD) in diffuse midline gliomas (DMGs) can lead to devastating symptoms such as severe pain, urinary incontinence, and tetraparesis, with limited treatment options. We determined whether detecting H3F3A K27M-mutant droplets in cerebrospinal fluid (CSF) circulating tumor deoxyribonucleic acid (ctDNA) could be a biomarker for detecting LMD in DMGs.

Methods: Twenty-five CSF samples were obtained from 22 DMG patients.

View Article and Find Full Text PDF

Aim: This study aimed to summarise and analyse the magnetic resonance imaging (MRI) characteristics of patients with myelin oligodendrocyte glycoprotein-immunoglobulin G-associated disease (MOGAD), and to enhance the accuracy of disease diagnosis and advance scientific research.

Materials And Methods: A retrospective collection of clinical data from 103 patients with MOGAD was conducted. The distribution and signal characteristics of intracranial lesions on MRI were analysed.

View Article and Find Full Text PDF

Objective: Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) is a novel steroid sensitive autoimmune disease, without a diagnostic consensus. The purpose of this study was to improve early GFAP-A diagnosis by increasing awareness of key clinical characteristics and imaging manifestations.

Methods: Medical records of 13 patients with anti-GFAP antibodies in serum or cerebrospinal fluid (CSF) were reviewed for cross-sectional and longitudinal analysis of clinical and magnetic resonance imaging (MRI) findings.

View Article and Find Full Text PDF
Article Synopsis
  • Adult primary leptomeningeal gliomatosis (PLG) is a rare and aggressive disease that affects the meninges with glial tumor infiltration but no obvious brain mass, and it has not been thoroughly studied at the molecular level.
  • In a study of six PLG patients, all showed leptomeningeal enhancement; most were diagnosed via biopsy revealing astrocytic gliomas with notable genetic mutations, including IDH-wildtype and TERT promoter alterations, which indicated similarities to adult-type glioblastoma.
  • All patients unfortunately died from the disease, with a median survival of just 24 days after diagnosis, although one case with early intervention survived significantly longer, suggesting that early detection and treatment may
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!