Reverse vesicles exhibiting functions similar to those of normal vesicles have been constructed through the self-assembly of TTF/CBPQT(4+)-based pseudo[2]rotaxanes in a nonpolar solvent. The ends of the threads of the pseudo[2]rotaxanes are attached with a Fréchet-type G-3 dendron and a hydrogen-bonded arylamide foldamer. These vesicles exhibit a response to redox. By exploiting the dynamic feature-spontaneously slow disassociation of the pseudorotaxanes-the sustained release of dyes embedded in the reverse vesicles has been demonstrated, which can be further tuned by changing the solvent polarity.
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http://dx.doi.org/10.1021/la302818r | DOI Listing |
Nanomaterials (Basel)
December 2024
School of Materials Science & Engineering, Nanyang Technological University, Singapore 639798, Singapore.
This study investigates the effects of homopolymer additives and kinetic traps on the self-assembly of poly(ethylene glycol)-b-poly(lactide) (PEG-PLA) block copolymer (BCP) nanostructures in aqueous environments. By using non-adsorbing PEG homopolymers to kinetically trap PEG-PLA nanostructures, we demonstrate that varying the concentration and molecular weight of the added PEG induces a reversible micelle-to-vesicle transition. This transition is primarily driven by changes in the molecular geometry of the PEG-PLA BCPs due to excluded volume screening effects.
View Article and Find Full Text PDFTransl Neurodegener
December 2024
Department of Neurosciences, Hengyang Medical School, University of South China, Hengyang, 421009, China.
Background: Neurological complications are a significant concern of Coronavirus Disease 2019 (COVID-19). However, the pathogenic mechanism of neurological symptoms associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is poorly understood.
Methods: We used Drosophila as a model to systematically analyze SARS-CoV-2 genes encoding structural and accessory proteins and identified the membrane protein (M) that disrupted mitochondrial functions in vivo.
Adv Sci (Weinh)
December 2024
Animal-Derived Food Safety Innovation Team, College of Veterinary Medicine, Anhui Agricultural University, Hefei, 230036, China.
The increasing occurrence of infections caused by multidrug-resistant (MDR) bacteria drives the need for new antibacterial drugs. Due to the current lack of antibiotic discovery and development, new strategies to fight MDR bacteria are urgently needed. Efforts to develop new antibiotic adjuvants to increase the effectiveness of existing antibiotics and design delivery systems are essential to address this issue.
View Article and Find Full Text PDFInt Immunopharmacol
December 2024
Department of Nephrology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address:
Background: Adipose mesenchymal stem cells (ADSCs) exert beneficial effects on kidney disease through a paracrine mechanism. However, the specific molecular mechanisms by which ADSCs treat renal fibrosis are not yet fully understood. Therefore, it is crucial to clarify the therapeutic effects of ADSC-derived extracellular vesicles (ADSC-EVs) on the progression of renal fibrosis and their underlying mechanisms.
View Article and Find Full Text PDFToxicol In Vitro
December 2024
Laboratorio de Investigación en Patología Experimental, Hospital Infantil de México Federico Gómez, Avenida Dr. Márquez 162, Colonia Doctores, Cuauhtémoc, 06720 Ciudad de México, Mexico. Electronic address:
Benzo[ghi] perylene (b[ghi]p) is classified as non-carcinogenic to humans, and there are currently no occupational exposure models available to identify its effects. The aim of this work was to evaluate the effect of b[ghi]p on the lysosomes of NL-20 cells (a human bronchial cell line) exposed to 4.5 μM for 3 h.
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