We present a methodology for the design, construction and modification of synthetic gene networks. This method emphasizes post-assembly modification of constructs based on network behavior, thus facilitating iterative design strategies and rapid tuning and repurposing of gene networks. The ease of post-construction modification afforded by this approach and the ever-increasing repository of components within the framework will help accelerate the development of functional genetic circuits for synthetic biology.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492501 | PMC |
| http://dx.doi.org/10.1038/nmeth.2205 | DOI Listing |
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