Stress, asthma, and respiratory infections: pathways involving airway immunology and microbial endocrinology.

Brain Behav Immun

Department of Psychology, Southern Methodist University, 6116 N. Central Expressway, Dallas, TX 75206, USA.

Published: March 2013

AI Article Synopsis

  • Stress and infections are both linked to the development and worsening of asthma, but they have mostly been studied separately.
  • Researchers are now exploring how infections interact with psychological stress and affect asthma, particularly focusing on the airway's mucosal surface.
  • Evidence suggests that psychological stress affects both the immune response and the harmful traits of bacteria, which could influence asthma development and flare-ups.

Article Abstract

Stress and infections have long been independently associated with asthma pathogenesis and exacerbation. Prior research has focused on the effect of psychological stress on Th cells with particular relevance to atopic asthma. In this review, we propose new perspectives that integrate the role of infection in the relationship between psychological stress and asthma. We highlight the essential role of the mucosal epithelia of the airways in understanding the interaction between infections and the stress-asthma relationship. In addition, we review findings suggesting that psychological stress not only modulates immune processes, but also the pathogenic qualities of bacteria, with implications for the pathogenesis and exacerbation asthma.

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http://dx.doi.org/10.1016/j.bbi.2012.09.012DOI Listing

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