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Urinary congophilia as a predictive biomarker of lupus nephritis in pregnant and non-pregnant women with systemic lupus erythematosus.
Lupus
January 2025
Mansoura Nephrology and Dialysis Unit, Mansoura University, Mansoura, Egypt.
Background: Endoplasmic reticulum stress with protein misfolding has been introduced as a key pathogenetic mechanism in lupus nephritis (LN). Pregnancy is thought to exaggerate proteostasis, which leads to the accumulation of potentially pathogenic misfolded proteins in the urine, serum, and placenta particularly in women with preeclampsia. The detection of misfolded proteins is made using Congo red stain, which is referred to as congophilia.
View Article and Find Full Text PDFPathology of Gestational Trophoblastic Disease (GTD).
Hematol Oncol Clin North Am
December 2024
Department of Histopathology, North West London Pathology, Imperial College Healthcare NHS Trusts, London, UK; Department of Metabolism, Digestion and Reproduction, Imperial College Healthcare NHS Trusts, London, UK. Electronic address:
Gestational trophoblastic disease (GTD), comprising hydatidiform moles (HM) and gestational trophoblastic tumors (GTT), is extremely rare. HM originate from villous trophoblast and are considered preneoplastic. GTT originate from the intermediate, largely extravillous trophoblast and includes choriocarcinoma, placental site trophoblastic tumor, epitheloid trophoblastic tumor, and mixed trophoblastic tumor.
View Article and Find Full Text PDFExaggerated Hematopoiesis in the First-Trimester Twin Placenta with an Unusual Morphology: A Case Report.
Ann Clin Lab Sci
May 2024
Department of Pathology and Laboratory Medicine, the Warren Alpert School of Medicine of Brown University, and Women and Infants Hospital of Rhode Island, Providence, RI, USA.
Netrin-1, an epithelial-secreted protein, plays a key role in placental formation through the promotion of cytotrophoblast proliferation and placental vascular development. These effects are mediated through several receptors, including the deleted in colorectal cancer (DCC) receptor. Placenta accreta spectrum (PAS) is an exaggerated trophoblastic invasion into the uterine myometrium.
View Article and Find Full Text PDFBisphenol S moderately decreases the expression of syncytiotrophoblast marker genes and induces apoptosis in human trophoblast lineages.
Environ Pollut
February 2024
Department of Biomedical Sciences, Cancer Research Center, University at Albany, State University of New York, Rensselaer, NY, 12144, USA. Electronic address:
Bisphenol S (BPS) is currently used in the manufacturing of several household equipment such as water pipes and food containers. Hence, its entrance into the human body is almost inevitable. The presence of BPS in body fluids has been reported.
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