Techniques for arthroscopic partial-thickness and full-thickness RTC repairs continue to advance. When selecting an RTC repair technique, it is important to identify the tear pattern and adhere to the fundamentals of tendon mobilization and footprint preparation. Partial RTC tears greater than 50% in thickness can be reproducibly repaired with tear completion or transtendinous techniques with good clinical outcomes. Based on the available literature, small, less than 1-cm RTC tears can effectively be repaired with single-row techniques. Tears sized 1 cm to 3 cm can be repaired with either single-row, double-row, or transosseous-equivalent techniques based on surgeon comfort, tendon quality, and tissue mobility. Tears greater than 3 cm have shown superior results when transosseous-equivalent techniques are used. Further clinical studies are needed to definitively conclude the ideal RTC repair technique.
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http://dx.doi.org/10.1016/j.csm.2012.07.002 | DOI Listing |
Mol Biol Rep
January 2025
Goat Genetics and Breeding Division, ICAR-Central Institute for Research On Goats, Makhdoom, Farah, Mathura, 281 122, Uttar Pradesh, India.
Background: Extracellular matrix (ECM) proteins play a crucial role in regulating the biological properties of adherent cells. For cryopreserved fibroblasts, a favourable ECM environment can help restore their natural morphology and function more rapidly, minimizing post-thaw stress responses.
Methods And Results: This study explored the functional responses of cryopreserved enriched caprine adult dermal fibroblast (cadFibroblast) cells to structural [collagen-IV and rat tail collagen (RTC)] and adhesion ECM proteins (laminin, fibronectin, and vitronectin) under in vitro culture conditions.
Elife
December 2024
Centre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, United Kingdom.
A major challenge in the stem cell biology field is the ability to produce fully functional cells from induced pluripotent stem cells (iPSCs) that are a valuable resource for cell therapy, drug screening, and disease modelling. Here, we developed a novel inducible CRISPR-mediated activation strategy (iCRISPRa) to drive the expression of multiple endogenous transcription factors (TFs) important for in vitro cell fate and differentiation of iPSCs to haematopoietic progenitor cells. This work has identified a key role for IGFBP2 in developing haematopoietic progenitors.
View Article and Find Full Text PDFAntiviral Res
December 2024
Laboratoire Architecture et Fonction des Macromolécules Biologiques (AFMB), CNRS, Aix-Marseille Université, UMR7257, Marseille, France; European Virus Bioinformatics Center, Leutragraben 1, 07743, Jena, Germany. Electronic address:
Remdesivir (RDV, Veklury®) is the first FDA-approved antiviral treatment for COVID-19. It is a nucleotide analogue (NA) carrying a 1'-cyano (1'-CN) group on the ribose and a pseudo-adenine nucleobase whose contributions to the mode of action (MoA) are not clear. Here, we dissect these independent contributions by employing RDV-TP analogues.
View Article and Find Full Text PDFJ Am Acad Orthop Surg Glob Res Rev
September 2024
From the Cooper Medical School of Rowan University Camden, Camden, NJ (Ms. Gutowski, Mr. Romiyo, and Dr. Fedorka), and the Cooper University Healthcare Camden, Camden, NJ (Dr. Wright, Mr. Gentile, Dr. Hunter, and Dr. Fedorka).
Introduction: Socioeconomic status (SES) affects access to care for traumatic rotator cuff (RTC) tears. Delayed time to treatment (TTT) of traumatic RTC tears results in worse functional outcomes. We investigated disparities in TTT and hypothesized that individuals from areas of low SES would have longer time to surgical repair.
View Article and Find Full Text PDFArthrosc Tech
August 2024
Knee and Arthroscopy Unit, ICATME, Hospital Universitari Dexeus, Universitat Autònoma de Barcelona, Barcelona, Spain.
We describe a surgical technique to repair medial meniscus posterior root tears through a transtibial pullout repair with a subcortical button for tibial fixation. This technique allows progressive tensioning of the repaired root without losing tension both during suturing of the knots above the button and after the procedure, owing to the specific button configuration.
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