The impact of particle clustering and correlation upon the percolation behavior of polydisperse cylinders with finite hard core diameter is examined within an analogy to a lattice percolation problem. Percolation thresholds and percolation and backbone probabilities are explored as functions of the degree of clustering and extent of correlation among the inter-particle contacts. The percolation threshold and volume fractions occupied by the infinite network and by the cluster backbone are shown to be quite sensitive to the formation of inter-connected cliques of particles and to the presence of correlation among particle contacts.
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Sci Rep
January 2025
Department of Bone Joint, Binzhou Medical University Hospital, No. 661 Huanghe 2nd Road, Binzhou, 256600, China.
This study examines the biocompatibility, osteogenic potential, and effectiveness of polyether ether ketone (PEEK) composites for treating osteonecrosis, seeking to establish a theoretical basis for clinical application. A range of PEEK composite materials, including sulfonated polyether ether ketone (SPEEK), polydopamine-sulfonated polyether ether ketone (SPEEK-PDA), bone-forming peptide-poly-dopamine-sulfonated polyether ether ketone (SPEEK-PDA-BFP), and vascular endothelial growth factor-poly-dopamine-sulfonated polyether ether ketone (SPEEK-PDA-VEGF), were constructed by concentrated sulfuric acid sulfonation, polydopamine modification and grafting of bioactive factors. The experiments involved adult male New Zealand rabbits aged 24-28 weeks and weighing 2.
View Article and Find Full Text PDFTalanta
January 2025
Department of Laboratory Medicine, Taihe hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, China; Hubei Key Laboratory of Embryonic Stem Cell research, Hubei University of Medicine, Shiyan, 442000, Hubei, China; Clinical molecular diagnostic center, Taihe hospital, Hubei University of Medicine, Shiyan, Hubei, 442000, China. Electronic address:
Endothelial-to-mesenchymal transition (EndMT) plays a crucial role in the initiation and progression of atherosclerosis and various disease processes. Cluster of differentiation 31 (CD31) is a significant marker in EndMT. Detecting CD31 is essential for early-stage monitoring of EndMT and diagnosing atherosclerosis.
View Article and Find Full Text PDFEnviron Sci Technol
January 2025
Geomicrobiology, Department of Geosciences, University of Tübingen, 72076 Tübingen, Germany.
Iron(III) (oxyhydr)oxide minerals with varying particle sizes commonly coexist in natural environments and are susceptible to both chemical and microbial reduction, affecting the fate and mobility of trace elements, nutrients, and pollutants. The size-dependent reduction behavior of iron (oxyhydr)oxides in single and mixed mineral systems remains poorly understood. In this study, we used microbial and mediated electrochemical reduction approaches to investigate the reduction kinetics and extents of goethite and hematite.
View Article and Find Full Text PDFMycobacteriophages are viruses that specifically infect bacteria of the Mycobacterium genus. A substantial collection of mycobacteriophages has been isolated and characterized, offering valuable insights into their diversity and evolution. This collection also holds significant potential for therapeutic applications, particularly as an alternative to antibiotics in combating drug-resistant bacterial strains.
View Article and Find Full Text PDFInt J Pharm
January 2025
School of Engineering, Faculty of Science and Engineering, Macquarie University, Sydney, NSW 2109, Australia.
Intranasal drug delivery is a promising non-invasive method for administering both local and systemic medications. While previous studies have extensively investigated the effects of particle size, airflow dynamics, and deposition locations on deposition efficiency, they have not focused on the thickness of deposited particles, which can significantly affect drug dissolution, absorption and therapeutic efficacy. This study investigates the deposition patterns of dry powder particles within the nasal airway, specifically examining how factors such as flow rates, particle size, and particle cohesiveness influence deposition patterns and their thickness.
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