AI Article Synopsis
- Idiosyncratic adverse drug reactions (IADRs), particularly drug-induced liver injuries (DILI), are significant reasons for drug withdrawals due to safety concerns.
- Most IADRs result from the formation of reactive metabolites (RMs) that harm organ tissues by interacting with macromolecules.
- The pharmaceutical industry is working on improving the identification of potential drug candidates at the design stage, and a web tool called SpotRM can help track drugs associated with IADRs linked to RM formation.
Article Abstract
Idiosyncratic adverse drug reactions (IADRs) cause a broad range of clinically severe conditions of which drug induced liver injury (DILI) in particular is one of the most frequent causes of safety-related drug withdrawals. The underlying cause is almost invariably formation of reactive metabolites (RM) which by attacking macromolecules induc eorgan injuries. Attempts are being made in the pharmaceutical industry to lower the risk of selecting unfit compounds as clinical candidates. Approaches vary but do not seem to be overly successful at the initial design/synthesis stage. We review here the most frequent categories of mechanisms for RM formation and propose that many cases of RMs encountered within early ADME screening can be foreseen by applying chemical and metabolic knowledge. We also mention a web tool, SpotRM, which can be used for efficient look-up and learning about drugs that have recognized IADRs likely caused by RM formation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/1389557511313050009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!