AI Article Synopsis
- The study aimed to investigate the link between insulin resistance and stroke risk in the elderly population, using data from the Rotterdam Study involving 5,234 stroke-free and diabetes-free participants aged 55 and older.
- During a follow-up period of over 42,000 person-years, 366 strokes occurred, but analyses revealed that fasting insulin levels and homeostasis model assessment for insulin resistance showed no association with the risk of any type of stroke.
- The findings suggest that markers of insulin resistance are not significant risk factors for stroke or its subtypes in this population of nondiabetic elderly individuals.
Article Abstract
Insulin resistance, which plays a key role in the development of diabetes mellitus, is a putative modifiable risk factor for stroke. The aim of this study was to investigate if markers of insulin resistance were associated with risk of stroke in the general elderly population. This study was part of the large population-based Rotterdam Study and included 5,234 participants who were aged 55 years or older and stroke free and diabetes free at baseline (1997-2001). Fasting insulin levels and homeostasis model assessment for insulin resistance were used as markers for insulin resistance. Cox regression was used to determine associations between insulin resistance markers and stroke risk, adjusted for age, sex, and potential confounders. During 42,806 person-years of follow-up (median: 8.6 years), 366 first-ever strokes occurred, of which 225 were cerebral infarctions, 42 were intracerebral hemorrhages, and 99 were unspecified strokes. Fasting insulin levels were not associated with risk of any stroke, cerebral infarction, or intracerebral hemorrhage. Homeostasis model assessment for insulin resistance, which almost perfectly correlated with fasting insulin levels, was also not associated with risk of stroke or stroke subtypes. In conclusion, in this population-based cohort study among nondiabetic elderly, insulin resistance markers were not associated with risk of stroke or any of its subtypes.
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| http://dx.doi.org/10.1093/aje/kws149 | DOI Listing |
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