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| http://dx.doi.org/10.1016/j.jcv.2012.09.001 | DOI Listing |
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Co-detection of various viruses in SARS-CoV-2 in children with respiratory infections.
Sci Rep
March 2025
College of Medicine, Chang Gung University, Taoyuan, Taiwan.
The co-detection of SARS-CoV-2 variant with other respiratory virus has been extensively investigated. However, conclusive evidence remains elusive and conflicted. This study investigated the source- and age-dependent prevalence, incidence, and co-detection of multiple viral infections in children younger than 18 years old who presented with clinical symptoms indicative of respiratory infections during SARS-CoV-2 pandemic.
View Article and Find Full Text PDFRhinoviral Infection of the Human Lung Vascular Endothelium May Protect From the Secondary Infection With Rhinovirus RV-16.
APMIS
March 2025
Department of Immunology and Allergy; Chair of Pulmonology, Rheumatology and Clinical Immunology, Medical University of Lodz, Lodz, Poland.
Rhinoviruses are a major cause of respiratory infections, including asthma infectious exacerbations. Human rhinovirus 16 (RV-16) has been widely shown to infect respiratory epithelial cells and the human lung vascular endothelium. RV-16 was also observed to induce an IFN-β-dependent mechanism of antiviral intracellular mechanisms based on OAS-1 and PKR activity.
View Article and Find Full Text PDFRespiratory Symptoms and Health Outcomes of Rhinovirus and Influenza Virus Infections: Implications of Asthma, Diabetes Mellitus and Allergic Rhinitis in Rhinovirus C Infection.
J Med Virol
March 2025
Department of Medical Microbiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Rhinovirus (RV), classified into RV-A, RV-B, and RV-C, is a prevalent cause of respiratory tract infections (RTIs). Here, we analysed RV infection and its clinical implications among outpatients with acute upper RTIs. Demographic data, baseline comorbidities, clinical symptoms, and health outcomes of RV-infected patients (n = 849) were compared with influenza (n = 417).
View Article and Find Full Text PDFQuantifying Rhinovirus Genomic and Negative-Strand RNA by RT-PCR.
Methods Mol Biol
February 2025
Department of Physiology and Pharmacology, and Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Molecular methods permit measurements of viral genomic RNA as well as of the negative-strand template generated during rhinovirus replication. As such, assays of negative-strand RNA can provide a means for relative quantification of levels of double-stranded RNA that is generated during replication and that interacts with pattern recognition receptors to activate the host immune response. Here we provide RT-PCR protocols for quantitative assays for rhinovirus genomic and negative-strand RNAs.
View Article and Find Full Text PDFMethod to Generate High-Titer Rhinovirus C Suitable for In Vitro and In Vivo Studies.
Methods Mol Biol
February 2025
Centre for Inflammation and Lung Research, Lewis Katz Medical School, Temple University, Philadelphia, PA, USA.
Rhinovirus (RV)-C, discovered in 2006, binds to human cadherin-related family member 3 expressed on ciliated cells. RV-C is the cause of severe respiratory illness in children with asthma. Unlike rhinovirus-A and B, very little is known about the RV-C biology or pathogenic mechanisms.
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