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Treatment of candidiasis: insights from host genetics. | LitMetric

Treatment of candidiasis: insights from host genetics.

Expert Rev Anti Infect Ther

Department of Internal Medicine, Radboud University Nijmegen MedicalCenter, P O Box 9101, 6500HB Nijmegen, The Netherlands.

Published: August 2012

AI Article Synopsis

Article Abstract

Candida species are major causes of mucosal and invasive infections, leading to substantial morbidity and mortality. Despite the development of new classes of antifungal drugs, mortality in patients with systemic candidiasis remains high. Host-Candida interaction plays an important role in effective elimination of the pathogen. Genetic studies have rendered important insights into antifungal host defense and have identified potential targets for adjunctive therapy. In this article, the authors review the genetic variations in the host defense to Candida and their implications for the treatment of mucosal and systemic candidiasis.

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Source
http://dx.doi.org/10.1586/eri.12.79DOI Listing

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