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Concurrent validity and discriminative ability of force plate measures of balance during the sub-acute stage of stroke recovery.
Gait Posture
December 2024
KITE Research Institute, Toronto Rehabilitation Institute-University Health Network, Toronto, ON, Canada; Evaluative Clinical Sciences, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada; Department of Physical Therapy, University of Toronto, Toronto, ON, Canada. Electronic address:
Background: Many objective measures of balance control, including force plate measures of standing balance, lack sufficient validation for use in the stroke population.
Research Questions: Do force plate measures of quiet standing balance during the sub-acute stage of stroke recovery have concurrent validity (i.e.
Sex Differences in Cardiovascular Adaptations Following Aerobic Exercise Training Programs: A Systematic Review and Meta-Analysis.
Can J Cardiol
December 2024
KITE Research Institute, Toronto Rehabilitation Institute - University Health Network Toronto, ON, Canada; Faculty of Health Sciences, Ontario Tech University, Oshawa, ON, Canada. Electronic address:
Background: The influence of aerobic exercise training on cardiovascular adaptations in healthy males versus females is unclear. This systematic review and meta-analysis summarized sex-based differences in cardiac adaptations following aerobic exercise training interventions in healthy adults.
Methods: Five electronic databases were searched from inception to June 2024.
Barriers and Facilitators Associated With Remote Concussion Physical Assessments From the Perspectives of Clinicians and People Living With Workplace Concussions: Focus Group Study.
J Med Internet Res
November 2024
Bruyère Research Institute, Ottawa, ON, Canada.
Background: Evaluating the clinical status of concussions using virtual platforms has become increasingly common. While virtual approaches to care are useful, there is limited information regarding the barriers and facilitators associated with a virtual concussion assessment.
Objective: This study aims to identify the barriers and facilitators associated with engaging in virtual concussion assessments from the perspective of people living with workplace concussions; identify the barriers and facilitators to completing virtual concussion assessments from the perspectives of clinicians; and identify the clinical measures related to 4 clinical domains that would be most appropriate in virtual practice: general neurological examination and vestibular, oculomotor, and cervical spine assessment.
Integrative single-cell multi-omics of CD19-CAR and CAR T cells suggest drivers of immunotherapy response in B cell neoplasias.
Cell Rep Med
November 2024
Josep Carreras Leukemia Research Institute, Barcelona, Spain; Spanish Network for Advanced Therapies, RICORS-TERAV, ISCIII, Spain; Spanish Collaborative Cancer Network, CIBERONC, ISCIII, Spain; Department of Biomedicine, University of Barcelona, Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain. Electronic address:
Article Synopsis
- The study investigates how the diversity of chimeric antigen receptor (CAR)-T cells affects clinical outcomes in treating B cell acute lymphoblastic leukemia (B-ALL).
- Researchers analyzed clonal dynamics and gene expression using single-cell techniques in patients receiving CD19CAR-T cells, revealing notable differences in how these T cells behave during treatment.
- Key findings include a higher CD4:CD8 ratio in successful patients' T cells at infusion and an expansion of cytotoxic T cells linked to better treatment responses across different patient cohorts.
Development of a closed-loop controller for functional electrical stimulation therapy plus visual feedback balance training for standing balance training.
Med Eng Phys
October 2024
Institute of Biomedical Engineering, University of Toronto, 164 College St., Toronto, ON, M5S 3G9, Canada; KITE-Toronto Rehabilitation Institute, University Health Network, 520 Sutherland Dr., Toronto, ON, M4G 3V9, Canada. Electronic address:
Individuals with incomplete spinal cord injury (iSCI) demonstrate impaired upright balance, resulting in increased fall risk. Task-specific visual feedback balance training (VFBT) has previously been shown to improve upright balance. In addition, therapies using functional electrical stimulation (FES) have been shown to improve various motor functions.
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