Complex diseases may be associated with combinations of changes in DNA, where the single change has little impact alone. In a previous study of patients with bipolar disorder and controls combinations of SNP genotypes were analyzed, and four large clusters of combinations were found to be significantly associated with bipolar disorder. It has now been found that these clusters may be connected to clinical data.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447882 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044623 | PLOS |
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