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| http://dx.doi.org/10.1371/journal.ppat.1002887 | DOI Listing |
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The fly route of extended-spectrum-β-lactamase-producing dissemination in a cattle farm: from the ecosystem to the molecular scale.
Front Antibiot
April 2024
Transmission, Reservoir and Diversity of Pathogens Unit, Institut Pasteur, Les Abymes, France.
Introduction: This study aimed to understand the origin and to explain the maintenance of extended-spectrum β-lactamase (ESBL) isolated from food-producing animals in a third-generation cephalosporin (3GC)-free farm.
Methods: Culture and molecular approaches were used to test molecules other than 3GC such as antibiotics (tetracycline and oxytetracycline), antiparasitics (ivermectin, flumethrin, fenbendazol, and amitraz), heavy metal [arsenic, HNO, aluminum, HNO, cadmium (CdSO), zinc (ZnCl), copper (CuSO), iron (FeCl), and aluminum (AlSO)], and antioxidant (butylated hydroxytoluene) as sources of selective pressure. Whole-genome sequencing using short read (Illumina™) and long read (Nanopore™) technologies was performed on 34 genomes.
Phytochemical characterization and anti-arthritic potential of green-synthesized CuO nanoparticles derived from the root extract.
Front Pharmacol
December 2024
Department of Pharmacy, University of Agriculture, Faisalabad, Pakistan.
Introduction: Rheumatoid arthritis is an autoimmune disease that mainly causes joint damage. The patient experiences loss of appetite, pain, fever, and fatigue. The present study was designed to phytochemically characterize and evaluate the anti-arthritic activity of green-synthesized copper oxide (CuO) nanoparticles (NPs) using the hydroalcoholic extract of roots in an adjuvant-induced arthritic rat model.
View Article and Find Full Text PDFAmalgamation of Metal Tolerant PGPR sp. EA20 with Birch Wood Biochar Enhanced Growth and Biofortification of Rapeseed under Copper Action.
Front Biosci (Elite Ed)
November 2024
Department of Life Sciences, GITAM School of Science, Gandhi Institute of Technology and Management, 530045 Visakhapatnam, Andhra Pradesh, India.
Background: Amalgamation of metal-tolerant plant growth promoting rhizobacteria (PGPR) with biochar is a promising direction for the development of chemical-free biofertilizers that can mitigate environmental risks, enhance crop productivity and their biological value. The main objective of the work includes the evaluation of the influence of prepared bacterial biofertilizer (BF) on biometric growth parameters as well as physiological and biochemical characteristics of rapeseed ( L.) at copper action.
View Article and Find Full Text PDFArticle Synopsis
- Bacterial blight in pomegranate, caused by Xanthomonas citri pv. punicae (Xcp), is a major issue leading to significant economic losses, with current management primarily relying on antibiotics and copper-based treatments.
- The excessive use of antibiotics has led to antibiotic resistance, prompting research into eco-friendly alternatives like native endophytes, which are beneficial bacteria isolated from pomegranate plants that can inhibit Xcp growth through the production of antimicrobial volatiles.
- Field trials showed that using these endophytes reduced the disease index by 47-68%, outperforming traditional chemical treatments, making them promising candidates for sustainable bacterial blight management in pomegranate cultivation.
Effect of micronutrients on the risk of Graves' disease: a Mendelian randomization study.
Front Nutr
December 2024
Department of Endocrinology and Metabolism, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Background: Micronutrient research on Graves' disease (GD) is limited and controversial. Therefore, in order to explore possible correlations between genetically predicted amounts of six micronutrients [Copper (Cu), Iron (Ir), Zinc (Zn), Calcium (Ca), Vitamin C (VC), and Vitamin D (VD)] and GD risk, we carried out Mendelian randomization research (MR).
Methods: We conducted an MR analysis using genome-wide association studies (GWAS) from people of European ancestry and aggregated information from UK Biobank to provide insight into the relationships between micronutrients and GD.
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