AI Article Synopsis
- Extraosseous plasmacytoma is a rare, slow-growing tumor that makes up a small percentage of plasma cell neoplasms, typically occurring outside of bones.
- Reports of these tumors in the central nervous system (CNS) are uncommon and are usually linked to other nasal lesions.
- This case study highlights an aggressive form of extraosseous plasmacytoma in an HIV-positive patient, uniquely presenting in the CNS with evidence of EBV expression, manifested as both a brain mass and in cerebrospinal fluid (CSF).
Article Abstract
Extraosseous (extramedullary) plasmacytoma is a relatively indolent neoplasm that constitutes 3-5% of all plasma cell neoplasms. Rare cases have been reported to truly occur in the CNS and not as an extension from a nasal lesion. EBV expression in plasma cell neoplasms has been reported in very few cases that are mainly post-transplant or occurring in severely immunosuppressed patients. We report a case of extraosseous plasmacytoma with an aggressive course in an HIV-positive individual that occurred solely in the CNS, showing EBV expression by in situ hybridization, and presenting as an intraparenchymal mass as well as in the CSF.
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| http://dx.doi.org/10.1111/j.1440-1789.2012.01352.x | DOI Listing |
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Article Synopsis
- Plasmacytomas are harmful tumors formed by the unusual growth of plasma cells and can occur in bones or soft tissues, with extramedullary types being rare, especially in the head and neck region.
- An 80-year-old male was treated for a localized plasmacytoma in the nasal septum, successfully removed via endoscopic surgery, followed by radiation therapy, and has shown no signs of recurrence after one year.
- Effective management of plasmacytomas requires a teamwork approach for diagnosis and treatment, and it's crucial to check for any broader systemic involvement before confirming a diagnosis of solitary plasmacytoma.
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