The effect of infliximab (1 and 10 mg/kg, i.p., during 10 days) on alcoholic steatohepatitis has been studied in rats fed with ethanol-containing liquid diet over 10 weeks. Both doses of infliximab showed immunomodulatory and anti-inflammatory effects, whereas only the maximum drug dose significantly decreased lipid accumulation in the liver. It can be concluded that infliximab (10 mg/kg) acts as an effective hepatoprotector, anti-inflammatory agent, and immunomodulator in rats with experimental alcoholic steatohepatitis.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
experimental alcoholic
8
infliximab mg/kg
8
alcoholic steatohepatitis
8
[hepatoprotective immunomodulatory
4
immunomodulatory effects
4
infliximab
4
effects infliximab
4
infliximab experimental
4
alcoholic steatohepatitis]
4
steatohepatitis] infliximab
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!