AI Article Synopsis
- Ultrahigh-resolution optical coherence tomography (UR-OCT) is being utilized for the first time to investigate single-cell basal cell carcinoma (BCC) in vitro, providing a noninvasive, label-free imaging method.
- The technique allows for three-dimensional analysis of BCC cells, enabling easy identification of live and dead cells based on their morphology.
- A new method was developed to automatically extract key parameters from cell data, showing that UR-OCT can effectively detect cell death at the cellular level.
Article Abstract
Ultrahigh-resolution optical coherence tomography (UR-OCT) has been used for the first time to our knowledge to study single-cell basal cell carcinoma (BCC) in vitro. This noninvasive, in situ, label-free technique with deep imaging depth enables three-dimensional analysis of scattering properties of single cells with cellular spatial resolution. From three-dimensional UR-OCT imaging, live and dead BCC cells can be easily identified based on morphological observation. We developed a novel method to automatically extract characteristic parameters of a single cell from data volume, and quantitative comparison and parametric analysis were performed. The results demonstrate the capability of UR-OCT to detect cell death at the cellular level.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447553 | PMC |
| http://dx.doi.org/10.1364/BOE.3.002111 | DOI Listing |
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