AI Article Synopsis
- The study used 24 Wistar strain albino rats to investigate the effects of lecithin on liver damage induced by d-galactosamine (d-GalN).
- Rats were pretreated with lecithin before d-GalN exposure, resulting in significantly lower liver enzyme levels and improved liver histopathology compared to untreated controls.
- Lecithin also prevented mitochondrial damage and changes in mRNA levels of Bax (upregulated) and Bcl-2 (downregulated), supporting its protective role against d-GalN-induced liver injury.
Article Abstract
Twenty four Wistar strain albino rats were used for the investigations. Lecithin 50 and 100 mg/kg b wt was administered for 1 week by oral route. Liver damage was induced by intra peritoneal administration of 400 mg/kg b wt d-galactosamine on the last day. At the end of the study animals were sacrificed and liver enzyme levels, histopathology, mitochondrial integrity, expression of p53, Bax and Bcl-2 mRNA levels were studied. Increases in the liver enzyme levels by d-GalN were significantly inhibited by pretreatment with lecithin. Histopathological observation further confirmed the hepatoprotective effect of lecithin. In addition, the disruption of mitochondrial membrane, up regulation of Bax and down regulation of Bcl-2 mRNA levels in the liver of d-GalN intoxicated rats were effectively prevented by pretreatment with lecithin. The results of the present study validate our conviction that d-GalN causes hepatic damage via mitochondrial pathway involving Bax and Bcl-2.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210239 | PMC |
| http://dx.doi.org/10.1007/s12291-011-0155-x | DOI Listing |
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