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Adherence to perindopril/amlodipine/atorvastatin combination according to the administration strategy.
Eur Heart J Qual Care Clin Outcomes
January 2025
University of Milano-Bicocca (Emeritus Professor), Milan, Italy.
Aims: To compare adherence to perindopril/amlodipine/atorvastatin combination administrated as a polypill (one pill) vs separate tablets.
Methods: Using the healthcare utilization database of Lombardy (Italy), 1 110 patients who received the perindopril/amlodipine/atorvastatin polypill during 2019-2021 were matched with 1 110 patients prescribed the same combination in separate tablets or as two antihypertensive drugs in a single tablet and the lipid-lowering drug tablet separately. Adherence to treatment was assessed over the year after the first perindopril/amlodipine/atorvastatin dispensation as the proportion of the follow-up days covered by prescription (PDC).
Integrating Dermocosmetic Therapy for Acne: Addressing Severity Levels in Real-Life Experiences.
J Drugs Dermatol
January 2025
Background: Acne is prevalent in approximately 80% of individuals aged 11 to 30 years, with scarring occurring in about 40% of cases. Early and sustained treatment is crucial for preventing acne scarring, regardless of severity.
Objectives: The objective of this study was to evaluate skin tolerability and patient compliance after combining a specific dermatologic routine with pharmacological therapy in patients affected by different degrees of acne.
[Parenteral nutrition in neonatology and pediatrics: physicochemical stability, risks and precautions. Narrative review].
Andes Pediatr
October 2024
Departamento de Gastroenterología y Nutrición Pediátrica, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Parenteral nutrition is a high-risk therapy due to some of its components and the exceptional inclusion of drugs. It can contain more than 50 nutrients, with different characteristics of osmolarity, ionic charge, and pH, which can affect its physicochemical stability. In addition, environmental conditions such as light, temperature, and oxygen must be considered.
View Article and Find Full Text PDFPatterns of Opioid and NSAID Use in Saudi Arabia from 2010 to 2020.
J Psychoactive Drugs
January 2025
Department of Pharmaceutical Care, King Fahad Medical City, Riyadh, Saudi Arabia.
The use of analgesics has increased globally over the last three decades. Prescription drug abuse has increased significantly, and opioids have been identified as causing further harm to the world. This study explored the utilization and expenditure associated with opioids and non-steroidal anti-inflammatory drugs (NSAIDs) from 2010 to 2020 in Saudi Arabia.
View Article and Find Full Text PDFValidation and Utility of Drug-Nutrient Interaction and Dietary Supplement Mechanistic Activity in the Natural Medicines Database.
JCO Oncol Adv
December 2024
Fred Hutchinson Cancer Center, Public Health Sciences Division, Seattle, WA.
Purpose: The increasing use of dietary supplements by patients with cancer and other chronic diseases requires the systematized review of potential interactions between prescription drugs and nutrients from supplements by health care and clinical research teams. Dietary supplement interaction databases are positioned to fill a gap in quantifying potential risks for patients, although none have been assessed for reliability in data interpretation. The NatMed database, a source for comprehensive reports on mechanistic and safety data for dietary supplement ingredients, was evaluated for use in future investigations.
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