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Utilizing machine learning approaches to investigate the relationship between cystatin C and serious complications in esophageal cancer patients after esophagectomy.
Support Care Cancer
December 2024
Department of Clinical Nutrition, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.
Background: The purpose of this study is to investigate the relationship between preoperative cystatin C levels and the risk of serious postoperative complications in esophageal cancer (EC) patients, utilizing advanced machine learning (ML) methodologies.
Methods: We conducted an observational cohort study, involving 524 EC patients from December 2014 to July 2022. ML models, including logistic regression (LR) and multilayer perceptron (MLP), were applied to investigate the relationship between cystatin C and the serious postoperative complications.
Meeting of minds: Skinner and Michotte at the International Congress of Psychology, Stockholm, 1951.
J Exp Anal Behav
November 2024
Keele University, Staffordshire, UK.
This note discusses the apparently unpublished correspondence between B. F. Skinner and the Belgian psychologist Albert Michotte, preceding Skinner's visit to the Thirteenth International Congress of Psychology in Stockholm in 1951.
View Article and Find Full Text PDF[Chinese expert consensus on the clinical diagnosis and treatment of gut microecology in chronic constipation (2024 edition)].
Zhonghua Wei Chang Wai Ke Za Zhi
April 2024
Chronic constipation is one of the common gastrointestinal disorders, with an incidence rate that is gradually increasing yearly and becoming an important chronic disease that affects people's health and quality of life. In recent years, significant progress has been made in the basic and clinical research of chronic constipation, especially the gut microbiota therapy methods have received increasing attention. Therefore, under the initiative of the Parenteral and Enteral Nutrition Branch of the Chinese Medical Association, Chinese Society for the Promotion of Human Health Science and Technology, and Committee on Gut Microecology and Fecal Microbiota Transplantation, experts from relevant fields in China have been organized to establish the "" committee.
View Article and Find Full Text PDFElectrochemical and Optical Sensors for the Detection of Chemical Carcinogens Causing Leukemia.
Sensors (Basel)
March 2023
Department of Pediatric Hematology, Oncology and Transplantology, Medical University, 20-093 Lublin, Poland.
Article Synopsis
- * Carcinogenesis, the process leading to cancer, can start with DNA mutations, often triggered by chemical carcinogens found in polluted environments and our diet.
- * The review aims to outline the chemical carcinogens linked to leukemia and discuss recent advances in detecting these harmful substances in the environment or food using electrochemical sensors.
Extended preconditioning on soft matrices directs human mesenchymal stem cell fate via YAP transcriptional activity and chromatin organization.
APL Bioeng
March 2023
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Center for Mitochondrial Biology and Medicine, School of Life Science and Technology, International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technology, Xi'an Key Laboratory for Biomedical Testing and High-End Equipment, Xi'an Jiaotong University, Xi'an 710049, People's Republic of China.
Dynamic extracellular matrix (ECM) mechanics plays a crucial role in tissue development and disease progression through regulation of stem cell behavior, differentiation, and fate determination. Periodontitis is a typical case characterized by decreased ECM stiffness within diseased periodontal tissues as well as with irreversible loss of osteogenesis capacity of periodontal tissue-derived human periodontal tissue-derived MSCs (hMSCs) even returning back to a physiological mechanical microenvironment. We hypothesized that the hMSCs extendedly residing in the soft ECM of diseased periodontal tissues may memorize the mechanical information and have further effect on ultimate cell fate besides the current mechanical microenvironment.
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