AI Article Synopsis
- Celiac disease (CD) is a condition triggered by gluten that causes damage to the intestines, leading to malabsorption, with a global prevalence around 1%, though it's unclear in this specific country.
- A retrospective study at the Anglo American Clinic reviewed medical records of 39 patients who tested positive for anti TTG antibodies, mainly older adults exhibiting symptoms like chronic diarrhea and abdominal pain.
- The findings suggest that CD should be considered in patients with prolonged gastrointestinal symptoms, and diagnosis should start with anti TTG testing followed by a duodenal biopsy for appropriate classification and staging.
Article Abstract
Background: Celiac disease (CD) is a condition in which gluten intake develops an autoimmune response generating intestinal villous atrophy, causing malabsorption. Prevalence worldwide is approximately 1%, in our country it is not known.
Material And Methods: Retrospective, descriptive, observational study in Anglo American Clinic between September 2004 and February 2012. We reviewed the medical charts, upper GI endoscopy reports and duodenal biopsy reports of all patients with positive anti TTG results, who were older than 18 years of age.
Results: We studied 39 cases, 26 (66.7%) women and 13 (33.3%) men. Mean age was 61.25 years. The symptoms were chronic diarrhea in 32 (82.1%), abdominal pain in 22 (56.4%), abdominal distention in 14 (35.9%), and others in lower frequency. Eight (20.5%) patients had anemia. Just 5 (12.8%) had upper endoscopy findings consistent with CD, and Marsh classification was: 0: 5 (12.7%), I: 1 (2.6%), II: 0 (0%), IIII A: 20 (51.3%), III B: 12 (30.8%) y III C: 1 (2.6%).
Conclusions: CD should be considered as a differential diagnosis of patients with non-specific long-term gastrointestinal symptoms, extraintestinal symptoms should also be taken into account. Diagnosis should be made with anti TTG as the initial test and posteriorly with a duodenal biopsy for staging.
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