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http://dx.doi.org/10.1016/j.jhsa.2012.07.009 | DOI Listing |
J Clin Invest
January 2025
How are autoreactive T cells induced and regulated in patients with autoimmune disease? This question lies at the core of understanding autoimmune disease pathologies, yet it has remained elusive due to host variability and the complexity of the immune system. In this issue of the JCI, Kramer and colleagues used autoimmune hepatitis (AIH) as a model to explore the maintenance of autoreactive CD4+ T cells specific to O-phosphoseryl-tRNA:selenocysteine tRNA synthase (SepSecS). The findings provide insight into the interaction between T cells and B cells in AIH pathogenesis that may reflect a shared mechanism among other autoimmune diseases.
View Article and Find Full Text PDFJ Gastrointest Oncol
December 2024
Department of Medical Oncology, University Hospital Antwerp, Edegem, Belgium.
AJR Am J Roentgenol
January 2025
Brown Radiology Human Factors Lab, Department of Diagnostic Imaging, Warren Alpert Medical School of Brown University, 593 Eddy Street, Providence, RI, USA.
J Rehabil Med
January 2025
Department of Biomedical, Surgical, and Dental Sciences, University of Milan "La Statale", Milan, Italy; IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.
The growing relevance of rehabilitation in healthcare to address increasing patient needs necessitates robust Physical and Rehabilitation Medicine (PRM) integration into medical education and practice. Academic PRM, rooted in medical faculties, is vital for developing the medical speciality as an academic discipline across Europe, where it faces challenges, including limited representation in medical schools and competition for resources with established disciplines. This commentary advocates establishing a representative organization for academic PRM in Europe.
View Article and Find Full Text PDFJ Am Board Fam Med
December 2024
From the University of New Mexico Clinical Translational Sciences Center, Department of Family & Community Medicine, University of New Mexico Health Sciences Center (NP); Department of Family and Community Medicine, Penn State College of Medicine, Community-Engaged Research Core, Penn State Clinical and Translational Science Institute (AEZ); Iowa Research Network (IRENE), Department of Family Medicine, College of Pharmacy, University of Iowa (KK); Department of Family and Community Medicine, Penn State College of Medicine (WJT); Department of Family and Community Medicine, Penn State College of Medicine (DPR).
In this commentary, the authors present opportunities for the family medicine's strategic plan for research to build and expand research infrastructure by leveraging the federally funded Clinical and Translational Science and Clinical and Translational Research Awards programs. These include engaging patients and communities historically underrepresented in research throughout the research design, development, implementation, and dissemination process; building and expanding practice-based research networks; leveraging research resources, facilities, trainings, and mentorship opportunities; obtaining pilot funding; using informatics expertise to improve care quality; and embedding dissemination and implementation science expertise to promote the use of evidence-based interventions in real world clinical primary care settings.
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