A fluorous cinchona alkaloid ester has been developed as a chiral promoter for the asymmetric fluorination of β-ketoesters. It has comparable reactivity and selectivity to the nonfluorous versions of cinchona alkaloids and can be easily recovered from the reaction mixture by simple fluorous solid-phase extraction (F-SPE) and used for the next round of reaction without further purification.
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| http://dx.doi.org/10.3762/bjoc.8.138 | DOI Listing |
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Recyclable fluorous cinchona organocatalysts for asymmetric synthesis of biologically interesting compounds.
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