Suppressed Digit Span performance has been proposed as an embedded indicator for suboptimal effort detection in neuropsychological evaluations in Western societies, particularly in the USA. However, its effectiveness in Chinese countries remains unexplored. The purposes of this study were first to explore normative Digit Span performance patterns between the Taiwan and American standardization samples, then to examine performances of patients with traumatic brain injury and with psychiatric diseases on the embedded measures (the Digit Span Scaled Score, Vocabulary minus Digit Span difference score, Reliable Digit Span, and the longest string of digits forward and backward) through retrospective data analysis. The normative Digit Span performance differs between the two cultural populations. Although litigating and nonlitigating participants perform differently on these measures, further prospective studies are needed to explore this issue with comprehensive external corroborating validity data.
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http://dx.doi.org/10.1093/arclin/acs081 | DOI Listing |
Alzheimers Dement
December 2024
Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, Beijing, China.
Background: The DL-3-n-butylphthalide (NBP), a multi-target neuroprotective drug, improving cognitive impairment in patient with vascular cognitive impairment has been confirmed. The efficacy of NBP in patients with cognitive impairment due to Alzheimer's disease (AD) remains unknown. This study aimed to evaluate the efficacy and safety of NBP in patients with mild cognitive impairment (MCI) due to AD though a clinical randomized controlled trail.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Background: Education is a recognized modifiable dementia risk factor. To boost cognitive reserve and reduce dementia risk in Brazil's vulnerable populations, we conceived a literacy program (PROAME trial) targeting low-educated adults, aiming to explore how executive function and individual differences influence program effectiveness.
Method: We screened 130 adults, with 108 meeting enrollment criteria.
Alzheimers Dement
December 2024
Neurobehavioral Systems, Inc, Berkeley, CA, USA.
Background: Paper-and-pencil neuropsychological tests have traditionally been considered the "gold standard" for clinical testing in AD/ADRD, but they have significant limitations: They are time-consuming, costly to administer, vulnerable to examiner bias and error, and unavailable to some patients due to location, transportation challenges, and cost. Manual tests also fail to comprehensively analyze many aspects of test performance. Computerized neuropsychological test batteries have been developed to address these shortcomings.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Michigan, Ann Arbor, MI, USA.
Background: Caregiving, both cross-sectional and longitudinal, is often considered a stressful experience. Less is known about the effect of the caregiving experience or the associated stress on cognitive functioning of the care provider.
Method: Data are drawn from the Social Relations Study (SRS) and the Detroit Area Wellness Network (DAWN) Studies.
Background: There are no evidence-based exercise guidelines to reduce falls in people living with dementia (PWD). The purpose of this pilot randomized controlled trial (RCT) was to determine the 1) feasibility and acceptability, and 2) effect of exercise on cognition and falls (exploratory) relative to usual care alone among PWD.
Methods: We randomized PWD to the exercise (n = 21) or usual care group (n = 21) at two residential care facilities in our pilot parallel, assessor-blinded RCT (1:1) [NCT05488951].
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