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Modifying the antibacterial performance of cu surfaces by topographic patterning in the micro- and nanometer scale.
Biomater Adv
January 2025
Chair of Functional Materials, Department of Materials Science, Saarland University, 66123 Saarbrücken, Germany.
Antimicrobial surfaces are a promising approach to reduce the spread of pathogenic microorganisms in various critical environments. To achieve high antimicrobial functionality, it is essential to consider the material-specific bactericidal mode of action in conjunction with bacterial surface interactions. This study investigates the effect of altered contact conditions on the antimicrobial efficiency of Cu surfaces against Escherichia coli and Staphylococcus aureus.
View Article and Find Full Text PDFKnowledge, attitude, and perceptions of MENA researchers towards the use of ChatGPT in research: A cross-sectional study.
Heliyon
January 2025
Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, 22110, Jordan.
Background: Artificial intelligence (AI) technologies are increasingly recognized for their potential to revolutionize research practices. However, there is a gap in understanding the perspectives of MENA researchers on ChatGPT. This study explores the knowledge, attitudes, and perceptions of ChatGPT utilization in research.
View Article and Find Full Text PDFEvaluation of the Adherence of Patients to Immunosuppressive Drug Therapy After Liver Transplantation.
Exp Clin Transplant
December 2024
>From The Faculty of Health Sciences, Bursa Uludag University Faculty of Medicine, Bursa, Turkey.
Objectives: Adherence of patients to their immunosuppressive treatment protocol after liver transplant is critical for the health and longevity of the transplanted liver. This study aimed to evaluate and determine the factors affecting the adherence of patients to immunosuppressive therapy after liver transplant.
Materials And Methods: We conducted a cross-sectional descriptive study with patients who had undergone liver transplant in a university hospital between June 2021 and June 2022.
Assessment of a novel unidirectional mid-term absorbable barbed suture versus a competitor barbed suture for vaginal cuff closure after gynaecology surgery, study protocol of a randomized controlled trial - BARHYSTER.
BMC Surg
January 2025
Department of Obstetrics and Gynaecology, Krankenhaus Sachsenhausen, Frankfurt Am Main, Germany.
Background: Total laparoscopic hysterectomy (TLH) is nowadays the standard to treat benign and malignant disease occurring in the uterus, but the number of robotic-assisted surgeries is increasing worldwide. To facilitate the handling of sutures in a bi- and tri-dimensional plane, a new type of suture material has been developed, named barbed sutures, which are in use in different indications. In comparison to conventional suture materials, the barbs anchor the suture in the tissue, provide tissue approximation and prevent slippage without the need for knot tying.
View Article and Find Full Text PDFSacubitril/valsartan reduces proteasome activation and cardiomyocyte area in an experimental mouse model of hypertrophy.
J Mol Cell Cardiol Plus
March 2024
Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.
Sacubitril/valsartan (Sac/Val) belongs to the group of angiotensin receptor-neprilysin inhibitors and has been used for the treatment of heart failure (HF) for several years. The mechanisms that mediate the beneficial effects of Sac/Val are not yet fully understood. In this study we investigated whether Sac/Val influences the two proteolytic systems, the ubiquitin-proteasome system (UPS) and the autophagy-lysosomal pathway (ALP), in a mouse model of pressure overload induced by transverse aortic constriction (TAC) and in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) treated with endothelin-1 (ET1) serving as a human cellular model of hypertrophy.
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