Biomimetic total synthesis of (±)-garcibracteatone.

Org Lett

School of Chemistry and Physics, University of Adelaide, Adelaide, SA 5005, Australia.

Published: October 2012

The polycyclic polyprenylated acylphloroglucinol natural product garcibracteatone has been synthesized in four steps from phloroglucinol, using a strategy based on biosynthetic speculation. The key biomimetic transformation is a cascade of 7-endo-trig and 5-exo-trig radical cyclizations followed by a terminating aromatic substitution reaction.

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Source
http://dx.doi.org/10.1021/ol302524qDOI Listing

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