The polycyclic polyprenylated acylphloroglucinol natural product garcibracteatone has been synthesized in four steps from phloroglucinol, using a strategy based on biosynthetic speculation. The key biomimetic transformation is a cascade of 7-endo-trig and 5-exo-trig radical cyclizations followed by a terminating aromatic substitution reaction.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1021/ol302524q | DOI Listing |
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!