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Impact of hospital-related indicators on healthcare-associated infections and appropriateness of antimicrobial use according to a national dataset.
Sci Rep
December 2024
Department of Public Health Sciences and Paediatrics, University of Turin, Turin, Italy.
Healthcare-associated infections (HAIs) represent a major threat in Europe. Infection prevention and control (IPC) measures are crucial to lower their occurrence, as well as antimicrobial stewardship to ensure appropriate use of antibiotics. Starting from Italian national data, this study aimed at: (i) describing IPC indicators, prevalence of HAIs, antimicrobial use and appropriateness of antibiotic use in Italy; (ii) estimating effects of IPC variables on HAI prevalence and on the proportion of antibiotics without specific reason.
View Article and Find Full Text PDFEffects of capsulorhexis size and position on post-surgical IOL alignment.
Sci Rep
December 2024
Visual Optics Lab Antwerp (VOLANTIS), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
In cataract surgery, post-surgical stability of the intraocular lens plays a major role. This study aims to explore how the size and decentration of the capsulorhexis affect intraocular lens decentration and tilt by using numerical methods. Finite element models included zonules, ciliary body, capsular bag, and an IOL with two open-loop haptics were built.
View Article and Find Full Text PDFScientific imperialism and the American Equatorial Islands Colonization Project, 1935-1942.
Hist Sci
December 2024
Hacettepe University, Turkey.
Between 1935 and 1942, a total of 130 men, aged seventeen to twenty-four, mostly of indigenous Hawaiian heritage, colonized Howland, Baker, and Jarvis Islands for the United States, in rotation, over the course of twenty-six expeditions. As part of the American Equatorial Islands Colonization Project (AEICP), they compiled meteorological data, observed and recorded the natural life of their surroundings, collected specimens for the Bishop Museum in Honolulu, mapped the islands, and built a landing strip on Howland for Amelia Earhart. In doing so, they confirmed U.
View Article and Find Full Text PDFComprehensive mapping of genetic variation at Epromoters reveals pleiotropic association with multiple disease traits.
Nucleic Acids Res
December 2024
Aix-Marseille University, INSERM, TAGC, UMR 1090 Marseille, France.
There is growing evidence that a wide range of human diseases and physiological traits are influenced by genetic variation of cis-regulatory elements. We and others have shown that a subset of promoter elements, termed Epromoters, also function as enhancer regulators of distal genes. This opens a paradigm in the study of regulatory variants, as single nucleotide polymorphisms (SNPs) within Epromoters might influence the expression of several (distal) genes at the same time, which could disentangle the identification of disease-associated genes.
View Article and Find Full Text PDFInsight into dysregulated VEGF-related genes in diabetic retinopathy through bioinformatic analyses.
Naunyn Schmiedebergs Arch Pharmacol
December 2024
Ningxia Hui Autonomous Region People's Hospital, Ningxia Eye Hospital, No. 301 Zhengyuan North Street, Jinfeng District, Yinchuan City, 750004, Ningxia Hui Autonomous, China.
Diabetic retinopathy (DR) is a prevalent microvascular complication of diabetes mellitus. VEGF plays a pivotal role in the pathogenesis of DR. To characterize the VEGF-related genes in DR patients, the RNAseq dataset of DR and normal control were downloaded from the GEO database and analyzed using R package limma.
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