AI Article Synopsis
- The study investigated how mitochondrial function in the muscular coat of the small intestine is affected under normal conditions and during widespread purulent peritonitis (WPP) in male chinchilla rabbits.
- The results indicated a significant decrease in mitochondrial activity in the small intestine due to WPP.
- Among the metabolic drugs tested, cytoflavin showed greater effectiveness compared to neoton, as it improved mitochondrial function beyond normal levels by the fifth day post-surgery, suggesting its potential use in treating WPP-related complications.
Article Abstract
The functional activity of mitochondria of the muscular coat of small intestine (MCSI) has been studied in the normal state and under experimental widespread purulent peritonitis (WPP) conditions. The experiments have been carried out on a group of 55 male rabbits of chinchilla breed. It is established that, as a result of the WPP development, the functional activity of mitochondria in MCSI considerably decreases. The comparative analysis of the efficiency of metabolic drugs cytoflavin and neoton showed advantage of the citoflavin preparation, the administration of which allowed the indices of mitochondria in intact animals to be exceeded on the fifth day of postoperative period. The research results show expediency of a complex treatment of WPP using cytoflavin preparation for the normalization of biological oxidation processes and elimination of enteric insufficiency.
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