AI Article Synopsis
- The study aimed to investigate how P-glycoprotein (P-gp) is expressed in patients with chronic schistosomiasis and to see if this expression varies by gender or age, while also looking at its clinical importance.
- Researchers analyzed colonic tissue samples from 50 chronic schistosomiasis patients and compared them to a control group of 4 healthy individuals with no disease but a family history of colon cancer.
- Results showed that while P-gp expression was significantly higher in schistosomiasis patients, this increase was not linked to the patients' gender or age, suggesting that the body may use P-gp as a protective response to irritation from schistosome eggs.
Article Abstract
Objective: To study the expression of P-glycoprotein (P-gp) in patients with chronic schistosomiasis and its relationship with gender and age, and to explore its clinical significance.
Methods: The colonic mucosa specimens of 50 chronic schistosomiasis patients and 4 persons who had a family history of colon cancer but their physical examinations were normal (as a control group) were selected and the expressions of P-gp in the colonic gland of these samples were detected with the immunohistochemical staining method.
Results: Compared with the control group, the mean gray value of the positive particles of P-gp of colonic epithelial cells of the chronic schistosomiasis group was significantly reduced (P < 0.05), but positive unit values were significantly increased (P < 0.05), which meant the P-gp expression in colonic gland of the patients with chronic schistosomiasis was significantly increased, but this increase had no relationship with sex and age.
Conclusion: Chronic schistosomiasis may induce the increase of P-gp expression which may be a compensatory protection mechanism due to the stimulation of schistosome eggs to the colon tissues.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!