AI Article Synopsis
- The study examined how Cervi cornus Colla (CCC) affects the reconstruction of skin equivalent (SE), finding that its combination with hyaluronic acid (HA) resulted in a thicker epidermis compared to the control SE.
- Immunohistochemical analysis revealed that the presence of CCC and HA promoted the expression of important proteins like p63 in the basal layer and involucrin in the upper layer of the epidermis.
- The research concluded that CCC enhances the development of the epidermis, basement membrane, and extracellular matrix in SE reconstruction, indicating its potential as a beneficial addition in skin regeneration treatments.
Article Abstract
The aim of this study was to investigate the effects of Cervi cornus Colla (CCC) in the reconstruction of skin equivalent (SE). H&E staining showed that SE containing hyaluronic acid (HA) or HA and CCC had a thicker epidermis than the control SE. Immunohistochemical staining showed that p63 was mainly present at the basal layer of the epidermis in the HA and CCC model. Involucrin was obviously expressed in the upper layer of the epidermis in the HA and CCC model. Moreover, we observed that integrins α6 and β1 were strongly expressed along the basement membrane zone in the HA and CCC model, in which the dermis expressing type I collagen was more compact. In conclusion, our data indicate that CCC contributed to the formation of epidermis, basement membrane, and extracellular matrix in the reconstruction of SE and suggest that CCC may be a useful adjuvant in the reconstruction of SE.
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| http://dx.doi.org/10.1007/s00403-012-1283-8 | DOI Listing |
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