Traumeel S was used as monotherapy for salivary glands inflammatory and dystrophic disorders. The study showed the drug to be especially efficient by exacerbation of the recurrent disease but the results were poor by indolent disease and on the latter stages of dystrophic disorder. Traumel S may be recommended to be used in combined therapy for salivary glands inflammatory and dystrophic disorders treatment.
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Background: TREM2 is a lipid-sensing receptor expressed by microglial sub-populations within neuropathological microenvironments, whose downstream signaling promotes microglial survival, plasticity, and migration. Multiple loss-of-function variants strongly implicate TREM2 as a key regulator of Alzheimer's disease (AD) risk. Accordingly, TREM2 antibodies are currently in development to evaluate the therapeutic potential of TREM2 agonism in neurodegenerative diseases.
View Article and Find Full Text PDFBackground: TREM2 is a lipid-sensing receptor expressed by microglial sub-populations within neuropathological microenvironments, whose downstream signaling promotes microglial survival, plasticity, and migration. Multiple loss-of-function variants strongly implicate TREM2 as a key regulator of Alzheimer's disease (AD) risk. Accordingly, TREM2 antibodies are currently in development to evaluate the therapeutic potential of TREM2 agonism in neurodegenerative diseases.
View Article and Find Full Text PDFGeorgian Med News
October 2024
1Department of Therapeutic Stomatology, Poltava State Medical University, Ukraine.
Throughout their existence, people have sought to know what tomorrow holds for them. It was especially important to learn about a full life, illness or death. Science is the essence of human knowledge, which is organized according to certain principles, a real connection of judgments, predictions and problems of reality and its individual spheres or aspects.
View Article and Find Full Text PDFbioRxiv
November 2024
Dept. of Anatomy and Neurobiology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.
The RNA binding protein TIA1 is known to regulate stress responses. Here we show that TIA1 plays a much broader role in inflammatory cells, being required for the microglial sensome. We crossed TIA1 cKO mice (using a CX3CR1 driven cre element) to PS19 MAPT P301S tauopathy mice.
View Article and Find Full Text PDFUrologiia
May 2024
Rostov State Medical University, Rostov-on-Don, Russian Federation.
This review highlights modern aspects of the pathogenesis, diagnosis and treatment of bladder leukoplakia. The search was conducted using Medline, PubMed, and EMBASE databases. Data from a literature search indicate that leukoplakia of the bladder (LMP) is one of the controversial diseases of the urinary system, which is characterized by dystrophic and proliferative changes in the urothelium of Lietos triangle.
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