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Cholangiocarcinoma in Latin America: a multicentre observational study alerts on ethnic disparities in tumour presentation and outcomes.
Lancet Reg Health Am
December 2024
Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute - Donostia University Hospital, University of the Basque Country (UPV/EHU), San Sebastian, Spain.
Background: Cholangiocarcinoma (CCA) represents a global health challenge, with rising incidence and mortality rates. This study aimed to elucidate the clinical course and practices of CCA in Latin America.
Methods: This observational cohort study investigated individuals diagnosed with CCA between 2010 and 2023 at five referral centres across Latin America.
Neutralizing antibody correlate of protection against severe-critical COVID-19 in the ENSEMBLE single-dose Ad26.COV2.S vaccine efficacy trial.
Nat Commun
November 2024
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Assessment of immune correlates of severe COVID-19 has been hampered by the low numbers of severe cases in COVID-19 vaccine efficacy (VE) trials. We assess neutralizing and binding antibody levels at 4 weeks post-Ad26.COV2.
View Article and Find Full Text PDFDomain growth kinetics in active binary mixtures.
J Chem Phys
October 2024
Department of Physical Sciences, Indian Institute of Science Education and Research Mohali, Knowledge City, Sector 81, SAS Nagar, Mohali, Punjab 140306, India.
We study motility-induced phase separation in symmetric and asymmetric active binary mixtures. We start with the coarse-grained run-and-tumble bacterial model that provides evolution equations for the density fields ρi(r⃗,t). Next, we study the phase separation dynamics by solving the evolution equations using the Euler discretization technique.
View Article and Find Full Text PDFHarvesting Green Hydrogen from the Deep Blue: Seawater-Compatible SnSe-P Decorated Graphene-CNTs Based Electrocatalyst Under Universal pH.
Small
December 2024
Institute of Nano Science & Technology, Knowledge City, Sector-81, SAS Nagar, Mohali, Punjab, 140306, India.
Fabrication of cost-effective and robust metal-based electrocatalysts for hydrogen evolution reactions (HER) across the entire pH range has garnered significant attention in harvesting renewable energy. Herein, the fabrication of 3D high-surface Ni Foam-Graphene-Carbon Nanotubes (NGC) decorated with phosphorous-inserted tin selenide (SnSe-P) showcases unprecedented HER activity with minimal overpotentials across all pH ranges (52 mV in acidic, 93 mV in basic, and 198 mV in neutral conditions@10 mA cm) and stability at 1 A cm for 72 h. The as-designed catalyst shows a low overpotential of 122 mV@10 mA cm in alkaline seawater, achieved through controlled electronic distribution on Sn site after incorporation of P in NGC-SnSe-P.
View Article and Find Full Text PDFPurpose: For patients with metastatic hormone-sensitive prostate cancer (mHSPC), delaying progression to castration-resistant disease is important not only for overall survival (OS) but also for patients' quality of life. Darolutamide plus androgen-deprivation therapy (ADT) with docetaxel improved OS versus ADT and docetaxel in patients with mHSPC. The ARANOTE trial evaluated darolutamide and ADT without chemotherapy in patients with mHSPC.
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