AI Article Synopsis
- Japanese encephalitis (JE) is a severe brain infection that can cause symptoms like altered consciousness, convulsions, and headaches, but acute transverse myelitis (ATM) as a complication hasn't been documented before.
- A case study details a 40-year-old man who experienced sudden weakness and urinary issues following JE symptoms of fever and headache, confirmed by elevated IgM against the virus and MRI findings.
- The patient was treated with intravenous methyl prednisolone, which led to significant recovery and complete resolution of spinal lesions, emphasizing the need for early diagnosis of ATM in JE cases to prevent further complications.
Article Abstract
Japanese encephalitis (JE) is an epidemic encephalitis characterised by altered sensorium, convulsions, headache, brainstem signs with pyramidal and extrapyramidal features. Immune-mediated manifestation as acute transverse myelitis (ATM) has not been previously reported in JE. We describe a 40-year-old man who presented with an acute onset quadriparesis with urinary retention, which was preceded by fever and headache 3 weeks prior. He had elevated IgM titres against JE virus in serum and cerebrospinal fluid. MRI of cervico-thoracic spine demonstrated signal intensity alterations extending from C1 to D10 spinal segments. The patient was treated with intravenous methyl prednisolone for 5 days. He regained normal power at 6 months follow-up and repeat MRI study demonstrated complete resolution of the lesion. We conclude that in a case of JE, one should be vigilant for early diagnosis of possible complication as ATM, in which an early institution of immunomodulator therapy prevents adverse consequences.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544216 | PMC |
| http://dx.doi.org/10.1136/bcr-2012-007094 | DOI Listing |
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Article Synopsis
- Acute transverse myelitis (ATM) is a serious neurological disorder involving spinal cord inflammation, leading to sensory, motor, and autonomic issues.
- A 29-year-old woman experienced severe lower limb weakness, urinary issues, and sensory loss, with MRI confirming ATM and HCV infection present in her blood.
- The case underscores the need for awareness of ATM as a possible complication of hepatitis C, especially when there is infective endocarditis (IE) involved, as confirmed by blood cultures showing bacteria linked to IE.
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