A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 143

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 143
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 209
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3098
Function: getPubMedXML

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: Attempt to read property "Count" on bool

Filename: helpers/my_audit_helper.php

Line Number: 3100

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3100
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

A highly active bifunctional iridium complex with an alcohol/alkoxide-tethered N-heterocyclic carbene for alkylation of amines with alcohols. | LitMetric

AI Article Synopsis

  • - A new series of iridium(III) complexes with bidentate N-heterocyclic carbenes (NHCs) were synthesized, featuring functional groups like alcohols and ethers, which were effective catalysts for alkylating anilines using alcohols.
  • - Specifically, the biscationic Ir(III) complexes yielded over 99% of higher-order amines with a 1:1 ratio of reactants and low catalyst amounts, achieving results in short times without the need for bases.
  • - The stability of these complexes was confirmed, and various analytical methods were used to understand their structure and mechanism while successfully alkylating a wide range of aromatic amines.

Article Abstract

A series of new iridium(III) complexes containing bidentate N-heterocyclic carbenes (NHC) functionalized with an alcohol or ether group (NHC-OR, R = H, Me) were prepared. The complexes catalyzed the alkylation of anilines with alcohols as latent electrophiles. In particular, biscationic Ir(III) complexes of the type [Cp*(NHC-OH)Ir(MeCN)](2+)2[BF(4)(-)] afforded higher-order amine products with very high efficiency; up to >99% yield using a 1:1 ratio of reactants and 1-2.5 mol % of Ir, in short reaction times (2-16 h) and under base-free conditions. Quantitative yields were also obtained at 50 °C, although longer reaction times (48-60 h) were needed. A large variety of aromatic amines have been alkylated with primary and secondary alcohols. The reactivity of structurally related iridium(III) complexes was also compared to obtain insights into the mechanism and into the structure of possible catalytic intermediates. The Ir(III) complexes were stable towards oxygen and moisture, and were characterized by NMR, HRMS, single-crystal X-ray diffraction, and elemental analyses.

Download full-text PDF

Source
http://dx.doi.org/10.1002/chem.201201845DOI Listing

Publication Analysis

Top Keywords

iridiumiii complexes
8
iriii complexes
8
reaction times
8
complexes
5
highly active
4
active bifunctional
4
bifunctional iridium
4
iridium complex
4
complex alcohol/alkoxide-tethered
4
alcohol/alkoxide-tethered n-heterocyclic
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!