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Effect of PTX3 and voriconazole combination in a rat model of invasive pulmonary aspergillosis. | LitMetric

Effect of PTX3 and voriconazole combination in a rat model of invasive pulmonary aspergillosis.

Antimicrob Agents Chemother

sigma-tau Industrie Farmaceutiche Riunite S.p.A. Research and Development, Pomezia, Rome, Italy.

Published: December 2012

AI Article Synopsis

Article Abstract

This study evaluated the pharmacological activity of PTX3, administered in combination with voriconazole, in a rat model of pulmonary aspergillosis. The data indicated additive therapeutic activities of these compounds, as demonstrated by the amelioration of respiratory function changes, reduction of lung fungal burden, and increased survival. Overall, we provide clear evidence that the combination of PTX3 with a suboptimal dose of voriconazole might represent a therapeutic option under those clinical conditions where the use of voriconazole alone is not warranted for efficacy and tolerability reasons.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497210PMC
http://dx.doi.org/10.1128/AAC.01000-12DOI Listing

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