AI Article Synopsis
- Intolerance to fava beans in people with glucose-6-phosphate-dehydrogenase deficiency can cause severe hemolysis and kidney damage.
- A case study reveals acute kidney injury linked to favism, showing renal biopsy results of tubular necrosis and significant iron deposits in kidney cells.
- The presence of oxidative stress markers and specific immune cells indicate both glomerular and tubular damage, suggesting new treatment approaches for recovery from acute kidney injury in these patients.
Article Abstract
Intolerance to fava beans in subjects with glucose-6-phosphate-dehydrogenase deficiency (favism) may lead to severe hemolytic crises and decreased renal function. Renal biopsy findings exploring the molecular mechanisms of renal damage in favism have not been previously reported. We report a case of favism-associated acute kidney injury in which renal biopsy showed acute tubular necrosis and massive iron deposits in tubular cells. Interestingly, iron deposit areas were characterized by the presence of oxidative stress markers (NADPH-p22 phox and heme-oxigenase-1) and macrophages expressing the hemoglobin scavenger receptor CD163. In addition, iron deposits, NADPH-p22 phox, hemeoxigenase- 1 and CD163 positive cells were observed in some glomeruli. These results identify both glomerular and tubular involvement in favism-associated acute kidney injury and suggest novel therapeutic targets to prevent or accelerate recovery from acute kidney injury.
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| http://dx.doi.org/10.5414/CN107520 | DOI Listing |
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