We study asymptotic properties of diffusion and other transport processes (including self-avoiding walks and electrical conduction) on large, randomly branched polymers using renormalized dynamical field theory. We focus on the swollen phase and the collapse transition, where loops in the polymers are irrelevant. Here the asymptotic statistics of the polymers is that of lattice trees, and diffusion on them is reminiscent of the climbing of a monkey on a tree. We calculate a set of universal scaling exponents including the diffusion exponent and the fractal dimension of the minimal path to two-loop order and, where available, compare them to numerical results.
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http://dx.doi.org/10.1103/PhysRevE.85.051126 | DOI Listing |
ACS Omega
January 2025
Unconventional Computing Laboratory, University of the West of England, Coldharbour Ln, Stoke Gifford, Bristol BS16 1QY, U.K.
Sea urchins display complex bioelectric activity patterns, even with their decentralized nervous system. Electrophysiological recordings showed distinct spiking patterns. The baseline potential was about 8.
View Article and Find Full Text PDFNPJ Digit Med
January 2025
Digital Medicine Society, Boston, MA, USA.
We propose the addition of usability validation to the extended V3 framework, now "V3+", and describe a pragmatic approach to ensuring that sensor-based digital health technologies can be used optimally at scale by diverse users. Alongside the original V3 components (verification; analytical validation; clinical validation), usability validation will ensure user-centricity of digital measurement tools, paving the way for more inclusive, reliable, and trustworthy digital measures within clinical research and clinical care.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Department of Chemical Engineering, Stanford University, Stanford, CA 94305.
The crowded bacterial cytoplasm is composed of biomolecules that span several orders of magnitude in size and electrical charge. This complexity has been proposed as the source of the rich spatial organization and apparent anomalous diffusion of intracellular components, although this has not been tested directly. Here, we use biplane microscopy to track the 3D motion of self-assembled bacterial genetically encoded multimeric nanoparticles (bGEMs) with tunable size (20 to 50 nm) and charge (-3,240 to +2,700 e) in live cells.
View Article and Find Full Text PDFDokl Biochem Biophys
January 2025
Bakulev National Medical Research Center for Cardiovascular Surgery, Moscow, Russia.
The study presents a numerical parametric investigation of flow structures in channels with a longitudinal-radial profile zR = Const and a spherical dome at the base. The goal of the study was to examine the flow structures in these channels depending on the exponent N of the profile and the height of the dome, to determine the conditions that provide optimal centripetal swirling flow, analogous to blood flow in the heart chambers and major vessels. The investigation was conducted using a comparative analysis of flow structures in channel configurations zR = Const, carried out in two stages.
View Article and Find Full Text PDFAntibodies (Basel)
December 2024
Eli Lilly and Company, Lilly Corporate Center Indianapolis, Indianapolis, IN 46285, USA.
Background: The prediction of human clearance (CL) and subcutaneous (SC) bioavailability is a critical aspect of monoclonal antibody (mAb) selection for clinical development. While monkeys are a well-accepted model for predicting human CL, other preclinical species have been less-thoroughly explored. Unlike CL, predicting the bioavailability of SC administered mAbs in humans remains challenging as contributing factors are not well understood, and preclinical models have not been systematically evaluated.
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