AI Article Synopsis
- Rabies remains a significant public health issue, even with oral wildlife vaccination efforts in Europe, as evidenced by eight reported cases in Macedonia between 2011-2012.
- Genetic analysis of these isolates shows they belong to the Eastern European rabies group and share high nucleotide sequence identity in the nucleoprotein gene.
- The close genetic relationship among rabies isolates from Macedonia, Serbia, and Bulgaria indicates that wildlife plays a key role in the spread of the disease in this region.
Article Abstract
Rabies, a worldwide zoonosis, remains a public-health concern despite oral wildlife vaccination in Europe. After a ten-year break, Macedonia reported eight rabies cases in 2011-2012. Two countries (Serbia and Bulgaria) bordering Macedonia are reporting cases in domestic and wild animals. This report describes the genetic characterisation of eight isolates from Macedonia compared with representative samples from neighbouring countries. All of the isolates tested belong to the Eastern European group, with a high degree of nucleotide sequence identity in the nucleoprotein gene. The close genetic relationship between isolates from the three bordering countries suggests that wildlife is responsible for rabies movements in the region.
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| http://dx.doi.org/10.1007/s00705-012-1466-9 | DOI Listing |
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