AI Article Synopsis
- A branched Man(5) oligosaccharide was created using a method that involved several controlled glycosylation steps on a mannose-tetraol.
- The synthesis process utilized n-pentenyl orthoester glycosyl-donors, with NIS/BF(3)·Et(2)O as the promoter, in a dichloromethane (CH(2)Cl(2)) solvent.
- The n-pentenyl chain in the tetraol acceptor was added to improve the solubility of the starting material and to allow for easier modifications at the oligosaccharide's reducing end.
Article Abstract
A branched Man(5) oligosaccharide has been synthesized by sequential regioselective glycosylations on a mannose-tetraol with n-pentenyl orthoester glycosyl-donors promoted by NIS/BF(3)·Et(2)O, in CH(2)Cl(2). An extended n-pentenyl chain was incorporated into the tetraol acceptor to facilitate (a) the solubility of the starting tetraol in CH(2)Cl(2), and (b) future manipulations at the reducing end of the Man(5) oligosaccharide.
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| http://dx.doi.org/10.1039/c2ob26432c | DOI Listing |
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