Background: Surfactant protein D (SP-D) is produced in the lungs and additional mucosal surfaces. Systemic SP-D levels are previously associated to aging-related- and lifestyle-related disorders and predicts mortality in cardiovascular and lung diseases. However, the association between higher serum SP-D levels and mortality in the general population is unknown. We hypothesized that increased systemic levels of SP-D may be used as prognostic factor for assessing the mortality in the elderly.
Methods And Results: SP-D serum levels were measured in 689 elderly subjects and mortality ratios were investigated after a 13-year follow-up period. Survival analysis showed that increasing quartiles of serum SP-D levels were associated to mortality in 70+ year old women (hazard ratio [HR], 1.29; 95% confidence interval [CI], 0.93-1.78; p = 0.032) adjusted for age, smoking and BMI. Women with SP-D levels above 2100 ng/ml had significantly increased mortality when compared to elderly women with SP-D levels equal to or below 2100 ng/ml (HR, 1.45; 95% CI, 1.12-1.88; p = 0.005). The likelihood that the female twin with the highest SP-D level died first increased with increasing SP-D levels (p = 0.031) - that is, the bigger intra-pair difference in SP-D level, the higher the probability that the twin with the highest measure died first (odds ratio [OR], 1.66; p = 0.047).
Conclusion: The study demonstrates that higher circulating SP-D levels are associated with increased mortality rate in elderly women in this population-based cohort study. SP-D may serve as a biomarker to track the cardio-pulmonary health status in elderly women.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.imbio.2012.08.272 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sensitization to food allergens is associated with more severe wheezing in children.
Allergol Select
December 2024
Manisa Celal Bayar University, School of Medicine, Department of Pediatric Allergy and Pulmonology, Manisa, Turkey.
Aims: We investigated sensitization to food allergens as a prognostic factor for wheezing in children with recurrent wheezing and compared serum club cell 16 (CC16) and surfactant protein D (SP-D) among these children with and without sensitization to food allergens.
Materials And Methods: Children with recurrent wheezing were enrolled in this prospective cohort study. Specific IgE to five common food allergens (Fx5) was assessed at baseline, and children were followed-up for 1 year for new-onset wheezing episodes.
β-Caryophyllene attenuates oxidative stress and inflammatory response in LPS induced acute lung injury by targeting ACE2/MasR and Nrf2/HO-1/NF-κB axis.
Biochem Biophys Res Commun
February 2025
Division of Pharmaceutical Technology, Defence Research Laboratory, DRDO, Tezpur, Assam, 784001, India. Electronic address:
Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), is a clinical syndrome that can cause pulmonary edema, inflammation, oxidative stress, and immunological dysregulations. β-Caryophyllene (BCP), a natural bicyclic sesquiterpene, possesses a variety of pharmacological properties and has the potential to be a therapeutic agent. This study aimed to comprehend the effect of BCP on Nrf2/HO-1/NF-κB and ACE2/MasR axis in a rat model of ALI by lipopolysaccharide (LPS) and the underlying mechanisms during this process.
View Article and Find Full Text PDFNovel tools for evaluating COVID-19 at the emergency department: Surfactant protein D level and CHARISMA score.
Heliyon
November 2024
Trakya University School of Medicine, Department of Medical Biochemistry, Edirne, Turkey.
Article Synopsis
- The study aimed to identify serum surfactant protein D (SP-D) levels that can aid in the diagnosis and prognosis of COVID-19, while also developing a new prognostic scale called the CHARISMA Score.
- Researchers conducted assessments on 64 COVID-19 patients and 16 healthy individuals, comparing various subgroups based on factors such as PCR results and severity of illness, ultimately finding significant differences in serum SP-D levels.
- Results indicated that higher SP-D levels and CHARISMA scores correlated with greater disease severity and mortality risk, establishing the potential of these measures for predicting patient outcomes in COVID-19 pneumonia.
Could Serum Collectin-11, surfactant protein-A and D be suitable biomarkers for assessing pulmonary damage caused by Rhodococcus equi infection in foals on large farms?
Pol J Vet Sci
September 2024
Department of Companion Animals and Horses, University Equine Hospital, Vetmeduni Vienna, Vienna, Austria.
Rhodococcus equi (R. equi) is a primary cause of pyogranulomatous pneumonia of foals between three weeks and five months of age. Early diagnosis of rhodococcal pneumonia has always been considered a preferable approach as it can lead to more successful treatment and better outcomes.
View Article and Find Full Text PDFPoor prognostic factors for relapse of interstitial lung disease in microscopic polyangiitis: the Japanese multicentre REVEAL cohort study.
Arthritis Res Ther
December 2024
Department of Internal Medicine IV, Division of Rheumatology, Osaka Medical and Pharmaceutical University, Daigaku-Machi 2-7, Takatsuki, Osaka, 569-8686, Japan.
Background: This study investigated poor prognostic factors for the relapse of interstitial lung disease (ILD) in patients with microscopic polyangiitis (MPA) after remission induction therapy.
Methods: We enrolled patients diagnosed with MPA complicated by ILD according to the Chapel Hill Consensus definition from 2001 to 2023 in multiple institutions in the REVEAL cohort. All patients who were treated with immunosuppressive therapy were followed up, and those who relapsed with ILD were extracted in this study.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!