AI Article Synopsis
- - The study aimed to assess the safety and effectiveness of stoss therapy in increasing vitamin D levels in children with cystic fibrosis and low vitamin D levels over a year.
- - A total of 142 pediatric patients were reviewed, with 38 receiving stoss therapy and 37 serving as a control group without treatment.
- - Results showed that stoss therapy led to a significant and lasting increase in vitamin D levels at multiple time points, maintaining levels above the deficiency threshold compared to the controls.
Article Abstract
Objectives: To determine the safety and efficacy of stoss therapy on vitamin D levels over a 12 month period in children with cystic fibrosis and vitamin D deficiency (<75 nmol/L).
Study Design: Retrospective chart review of 142 paediatric CF patients from 2007 till 2011.
Results: Thirty eight children received stoss therapy and 37 children with vitamin D deficiency were not treated and served as a control group. The stoss treated group had a significant and sustained increase in 25-hydroxyvitamin D levels measured at 1, 3, 6 and 12 months post treatment compared to controls (94.82 ± 41.0 nmol/L, p=0.001; 81.54 ± 24.6 nmol/L, p=0.001; 92.18 ± 36.5 nmol/L, p=0.008 and 64.6 ± 20.0 nmol/L, p=0.006 respectively). At 12 months post intervention, the mean difference in vitamin D levels from baseline between the stoss treated group and controls was significant at 15 nmol/L compared to 5 nmol/L (p=0.038).
Conclusion: Stoss therapy effectively achieves and maintains levels of 25-hydroxyvitamin D greater than 75 nmol/L over 12 months.
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| http://dx.doi.org/10.1016/j.jcf.2012.08.007 | DOI Listing |
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