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Antiadhesive and antibacterial multilayer films via layer-by-layer assembly of TMC/heparin complexes. | LitMetric

Antiadhesive and antibacterial multilayer films via layer-by-layer assembly of TMC/heparin complexes.

Biomacromolecules

Grupo de Materiais Poliméricos e Compósitos, GMPC, Departamento de Química, DBS Bloco B-08, Universidade Estadual de Maringá UEM, Av. Colombo 5790, CEP 87020-900 Maringá, Paraná, Brazil.

Published: November 2012

N-Trimethyl chitosan (TMC), an antibacterial agent, and heparin (HP), an antiadhesive biopolymer, were alternately deposited on modified polystyrene films, as substrates, to built antiadhesive and antibacterial multilayer films. The properties of the multilayer films were investigated by Fourier transform infrared spectroscopy, atomic force microscopy, scanning electron microscopy, and Kelvin force microscopy. In vitro studies of controlled release of HP were evaluated in simulated intestinal fluid and simulated gastric fluid. The initial adhesion test of E. coli on multilayer films surface showed effective antiadhesive properties. The in vitro antibacterial test indicated that the multilayer films of TMC/HP based on TMC80 can kill the E. coli bacteria. Therefore, antiadhesive and antibacterial multilayer films may have good potential for coatings and surface modification of biomedical applications.

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Source
http://dx.doi.org/10.1021/bm3011962DOI Listing

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