The meridian-acupoint has response function and effect function. As a direct reflection between acupoint and diseased area, the response function is the foundation of the effect function, and skin resistance of acupoint is usually used as an objective indice for research of meridian-acupoint response. Among the skin resistance-based researches on specificity of meridian-acupoint reaction, the selection of instrument is a key point. At present the main measurement instruments for meridian-acupoint resistance include dual-electrode device and four-electrode device. After analyzing the characteristics and inter-ference factors of different types of measurement instruments for meridian-acupoint resistance, dual-electrode device is suitable for qualitative analysis, for its control of interference factors needs to improve. The four-electrode device is good at quantitative research, for it is easier to control interference factors. Yet, there is more for research department to do to improve the instrument design by modern scientific technique in order to meet need for research.
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Nat Commun
January 2025
MRC Laboratory of Medical Sciences, London, UK.
Gene enhancers often form long-range contacts with promoters, but it remains unclear if the activity of enhancers and their chromosomal contacts are mediated by the same DNA sequences and recruited factors. Here, we study the effects of expression quantitative trait loci (eQTLs) on enhancer activity and promoter contacts in primary monocytes isolated from 34 male individuals. Using eQTL-Capture Hi-C and a Bayesian approach considering both intra- and inter-individual variation, we initially detect 19 eQTLs associated with enhancer-eGene promoter contacts, most of which also associate with enhancer accessibility and activity.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
School of Life Sciences, Zhengzhou University, Henan, Zhengzhou 450001, China; School of Advanced Agricultural Sciences, Peking University, Beijing 100000, China; Longhu Laboratory, Henan, Zhengzhou 450001, China; Henan Key Laboratory of Immunobiology, Henan, Zhengzhou 450001, China; College of Veterinary Medicine, Henan Agricultural University, Henan, Zhengzhou 450001, China. Electronic address:
Autoimmune diseases are characterized by dysregulated immune responses and chronic inflammation. B cell activating factor (BAFF) and interleukin-17 (IL-17) are key mediators in the pathogenesis of several autoimmune diseases, driving B cell hyperactivation, autoantibody production, and tissue damage. Simultaneous targeting of these pathways may provide a synergistic therapeutic approach.
View Article and Find Full Text PDFCrim Behav Ment Health
January 2025
Department of Criminal Justice, Kutztown University, Kutztown, Pennsylvania, USA.
Background: The importation model holds that inmate behaviour is a function of behaviours and thought patterns offenders bring with them into prison from the community. It may also be that offenders export behaviours and thought patterns they develop or refine in prison when they return to the community.
Aims: The purpose of this study was to determine whether an increase in reactive criminal thinking in prisoners predicts recidivism following release.
Front Oncol
January 2025
School of Medicine, Razi Hospital, Ilam University of Medical Sciences, Ilam, Iran.
() infection is a typical microbial agent that interferes with the complex mechanisms of gastric homeostasis by disrupting the balance between the host gastric microbiota and mucosa-related factors, ultimately leading to inflammatory changes, dysbiosis, and gastric cancer (GC). We searched this field on the basis of PubMed, Google Scholar, Web of Science, and Scopus databases. Most studies show that inhibits the colonization of other bacteria, resulting in a less variety of bacteria in the gastrointestinal (GI) tract.
View Article and Find Full Text PDFAutophagy is an essential cellular process which functions to maintain homeostasis in response to stressors such as starvation or infection. Here, we report that a subset of autophagy factors including ATG-3 play an antiviral role in Orsay virus infection of . Orsay virus infection does not modulate autophagic flux, and re-feeding after starvation limits Orsay virus infection and blocks autophagic flux, suggesting that the role of ATG-3 in Orsay virus susceptibility is independent of its role in maintaining autophagic flux.
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