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Generalized functional varying-index coefficient model for dynamic synergistic gene-environment interactions with binary longitudinal traits.
PLoS One
January 2025
Department of Statistics and Probability, Michigan State University, East Lansing, MI, United States of America.
The genetic basis of complex traits involves the function of many genes with small effects as well as complex gene-gene and gene-environment interactions. As one of the major players in complex diseases, the role of gene-environment interactions has been increasingly recognized. Motivated by epidemiology studies to evaluate the joint effect of environmental mixtures, we developed a functional varying-index coefficient model (FVICM) to assess the combined effect of environmental mixtures and their interactions with genes, under a longitudinal design with quantitative traits.
View Article and Find Full Text PDFCharacterization of the putative yeast mitochondrial triacylglycerol lipase Tgl2.
J Biol Chem
January 2025
Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany. Electronic address:
Mitochondria derive the majority of their lipids from other organelles through contact sites. These lipids, primarily phosphoglycerolipids, are the main components of mitochondrial membranes. In the cell, neutral lipids like triacylglycerides (TAGs) are stored in lipid droplets, playing an important role in maintaining cellular health.
View Article and Find Full Text PDFTargeting Triple NK Cell Suppression Mechanisms: A Comprehensive Review of Biomarkers in Pancreatic Cancer Therapy.
Int J Mol Sci
January 2025
Department of Oncology, Vejle Hospital, University Hospital of Southern Denmark, 7100 Vejle, Denmark.
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor outcomes due to frequent recurrence, metastasis, and resistance to treatment. A major contributor to this resistance is the tumor's ability to suppress natural killer (NK) cells, which are key players in the immune system's fight against cancer. In PDAC, the tumor microenvironment (TME) creates conditions that impair NK cell function, including reduced proliferation, weakened cytotoxicity, and limited tumor infiltration.
View Article and Find Full Text PDFCurrent Evidence on the Relation Between Microbiota and Oral Cancer-The Role of -A Narrative Review.
Cancers (Basel)
January 2025
Otolaryngology Division, Azienda Ospedaliera Universitaria di Sassari, 07100 Sassari, Italy.
Oral squamous cell carcinoma (OSCC) is one the most prevalent head and neck cancers and represents a major cause of morbidity and mortality worldwide. The main established risk factors for OSCC include tobacco and alcohol consumption and betel quid chewing, which may contribute alone or in combination with other environmental factors to carcinogenesis. The oral microbiota is emerging as a key player in the establishment of the molecular and cellular mechanisms that may trigger or promote carcinogenesis, including in the oral cavity.
View Article and Find Full Text PDFCan I pickle Doc? Return to Pickleball and other Racket Sports after Total Joint Arthroplasty.
J Arthroplasty
January 2025
Department of Orthopaedic Surgery, University of Utah, Salt Lake City, UT, USA. Electronic address:
Background: Participation in pickleball and other racket sports is growing, particularly among older adults who may also be candidates for joint arthroplasty (JA). Currently, there is limited data on performance, safety, and return to racket sports after JA.
Methods: An online survey was sent to 7,200 patients who had undergone at least one primary JA at a single academic center over the past 10 years (five surgeons).
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