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Ganglioglioma with Mutation and Homozygous Deletion: A Case Report.
Br J Hosp Med (Lond)
October 2024
Department of Neuro-Oncology, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Gangliogliomas are grade 1 glioneuronal tumors occurring predominantly in the temporal lobe, as per the World Health Organization (WHO) classification. Gangliogliomas often harbor (v-Raf murine sarcoma viral oncogene homolog B1) p.V600E hotspot mutation or other alterations leading to activation of RAS/RAF/MAPK (rat sarcoma virus oncogene/rapidly accelerated fibrosarcoma/mitogen-activated protein kinase) signaling pathway, which is the driver factor of this tumor.
View Article and Find Full Text PDFContralateral transcallosal transfalcine approach for bilateral intra-extraventricular anaplastic ganglioglioma 'the trans-tumoral route': a technical case instruction.
Br J Neurosurg
September 2024
Neurosurgery Unit, Department of Head and Neck Surgery, Garibaldi Hospital, Catania, Italy.
Background: Bilateral, biventricular lesions present a challenging scenario in neurosurgery, often requiring complex surgical techniques for management. Gangliogliomas (GG), while typically indolent, can manifest as anaplastic variants (AGG), necessitating comprehensive treatment strategies. This case study explores a unique surgical approach for a patient with bilateral, intra-extraventricular lesions infiltrating the corpus callosum, highlighting the complexities of managing such cases.
View Article and Find Full Text PDF[Clinicopathological characteristics of gangliogliomas with anaplastic morphology].
Zhonghua Bing Li Xue Za Zhi
June 2024
Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing Geriatric Medical Research Centre, Beijing 100053, China National Center for Neurological Disorders, National Center for Neurological Disorders and Clinical Research Center for Epilepsy, Capital Medical University, Beijing 100053, China.
To investigate the clinical, radiological, and pathological features of anaplastic gangliogliomas (AGGs) and to determine whether these tumors represent a distinct entity. Consecutive 667 cases of ganglioglioma (GG) diagnosed at the Xuanwu Hospital, Capital Medical University, Beijing, China between January 2015 and July 2023 were screened. Among these cases, 9 pathologically confirmed AGG cases were identified.
View Article and Find Full Text PDFGanglioglioma with anaplastic/high-grade transformation: Histopathologic, molecular, and epigenetic characterization of 3 cases.
J Neuropathol Exp Neurol
May 2024
Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Minnesota, USA.
Article Synopsis
- Anaplastic ganglioglioma (GG) is a rare tumor with glial components that can become more aggressive over time, particularly in pediatric patients aged 9-16.
- In a study of three patients with BRAF p.V600E mutations, initial low-grade tumors transformed into higher-grade tumors at recurrence after a period ranging from 20 months to 7 years.
- The research suggests that the progression to a more malignant state in gangliogliomas may involve the inactivation of the CDKN2A/B genes, even though these deletions were not found in all initial tumors.
Cerebellar anaplastic ganglioglioma in a septuagenarian.
Radiol Case Rep
April 2024
Department of Surgery, Division of Neurosurgery, University of Toledo Medical Center, 3000 Arlington Ave Toledo, OH 43614, USA.
Ganglioglioma is a rare neoplasm most common in children and adolescents. It is typically located in the supratentorial compartment, with the temporal lobe being the most common tumor location. Anaplastic ganglioglioma is a WHO grade III ganglioglioma, a rare subtype accounting for a small minority of ganglioglioma cases.
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