This study examined the classification of initial dips during passive listening to single words by analysis of vectors of deoxyHb and oxyHb measurements simultaneously derived from near-infrared spectroscopy. The initial dip response during a single-word 1.5-s task in 13 healthy participants was significant only in the language area, which includes the left posterior superior temporal gyrus and angular gyrus. Event-related vectors of responses to comprehended words moved significantly into phase 4, a dip phase, whereas vectors of responses to unknown words moved into a nondip phase (P<0.05). The same results were reproduced after previously unknown words were learnt by the participants. Among the five dip phases, reflecting variations in transient oxygen metabolic regulation during a task, the frequency of occurrence of hypoxic-ischemic initial dips (decreased oxyHb) was around three times that of the canonical dip (increased deoxyHb and oxyHb). Phase classification of event-related vectors enhances the slight amount of oxygen exchange that occurs in word recognition, which has been difficult to detect because of its small amplitude.
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