AI Article Synopsis
- Proton pump inhibitors (PPIs) rarely cause acid-base imbalances or electrolyte disorders, but they can lead to metabolic acidosis or low potassium levels (hypokalemia) in specific situations.
- These effects are likely due to PPIs interfering with the proton pump's role in regulating hydrogen (H+) and potassium (K+) balance in the kidneys.
- A case is presented where significant hypokalemia and distal renal tubular acidosis occurred, suggesting that a PPI played a role in causing metabolic acidosis.
Article Abstract
Acid-base imbalances and electrolyte disorders induced by proton pump inhibitors (PPIs) are extremely rare. However, under certain conditions, PPIs may cause metabolic acidosis or hypokalemia, probably due to an inhibitory action on the proton pump that contributes to H(+) and K(+) homeostasis in the kidney. We herein present a case of marked hypokalemia accompanied by distal renal tubular acidosis in which a PPI appeared to contribute to the pathophysiology of metabolic acidosis.
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| http://dx.doi.org/10.2169/internalmedicine.51.7981 | DOI Listing |
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