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Unraveling the power of NAP-CNB's machine learning-enhanced tumor neoantigen prediction.
Elife
March 2025
Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
In this study, we present a proof-of-concept classical vaccination experiment that validates the in silico identification of tumor neoantigens (TNAs) using a machine learning-based platform called NAP-CNB. Unlike other TNA predictors, NAP-CNB leverages RNA-seq data to consider the relative expression of neoantigens in tumors. Our experiments show the efficacy of NAP-CNB.
View Article and Find Full Text PDFInvestigating the Utility of the BrainEye Smartphone Eye Tracking Application and Platform in Concussion Management.
Sports Med Open
March 2025
Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, 3004, Australia.
Background: Concussion is a common consequence of engaging in collision sports, with the often mild, transient nature of symptoms posing a considerable diagnostic and management challenge. This challenge is vastly magnified for athletes competing at grassroots/non-professional levels, who lack field side access to medical expertise in the assessment of a player's capacity to continue playing or need for further medical attention. The aim of this pilot study was to evaluate the utility of the BrainEye application and hardware (BrainEye platform) as a concussion screening tool, specifically determining (1) its sensitivity and specificity with respect to identifying an individual with a clinically diagnosed concussion, (2) the stability of the platform through test completion/failure rates, and (3) its usability through operator feedback and uptake/integration into concussion management protocols.
View Article and Find Full Text PDFBackground: Hidradenitis suppurativa (HS) is a chronic, recurrent, and debilitating inflammatory condition characterized by abscesses, comedones, and nodules. The heterogeneous presentation of HS often leads to diagnostic challenges, with clinical mimics such as cutaneous metastases (CMs) being of particular importance. CMs can present as initial manifestations of metastatic disease, necessitating accurate identification to guide potentially lifesaving treatment.
View Article and Find Full Text PDFEffect of high-dose N-acetyl cysteine on the clinical outcome of patients with diabetic peripheral neuropathy: a randomized controlled study.
Diabetol Metab Syndr
March 2025
Clinical Pharmacy Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Background: Diabetic peripheral neuropathy (DPN) is a vastly common and bothersome disorder with a clinically challenging course of treatment affecting patients with diabetes. This study aimed to evaluate the efficacy and safety of high dose oral N-acetyl cysteine (NAC) as adjuvant therapy on clinical outcome of DPN.
Methods: A prospective, randomized, parallel, open label, controlled clinical trial.
Initiating buprenorphine to treat opioid use disorder without prerequisite withdrawal: an updated systematic review.
Addict Sci Clin Pract
February 2025
University of Connecticut School of Pharmacy, 69 N. Eagleville Rd. Unit 3092, Storrs, CT, 06269, USA.
Background: Withdrawal prior to buprenorphine initiation may be intolerable or create barriers to therapy. We aim to update our previous systematic review on the efficacy and safety of buprenorphine initiation strategies that aim to omit prerequisite opioid withdrawal (POW).
Methods: We used the same search strategy for this update as in the original review with the modification of an additional term "low dose.
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