The structural characteristics of Francisella tularensis protective antigene complex (PAC) were discussed. PAC is the water-soluble antigene of outer membranes F. Tularensis with sophisticated chemical nature. The molecular weight of PAC is 280 kD. It was found that PAC is composed of some immunoreactivity protein subunits with molecular weight from 81 to 19 kD, and 14-17 kD lipoprotein subunit. The stress proteins-chaperones (GroES, GroEL), outer membrane proteins (FTL_0617, OmpH), receptor proteins (EF Tu, Rp1L), bacterial enzymes (KatG, GAPDH), and lipopolysaccharide were identified in the PAC structure. Their presence determines the PAC high immunobiological activity.
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