Soft elastomeric materials that mimic real soft human tissues are sought to provide realistic experimental devices to simulate the human body's response to blast loading to aid the development of more effective protective equipment. The dynamic mechanical behavior of these materials is often measured using a Kolsky bar because it can achieve both the high strain rates (>100s(-1)) and the large strains (>20%) that prevail in blast scenarios. Obtaining valid results is challenging, however, due to poor dynamic equilibrium, friction, and inertial effects. To avoid these difficulties, an inverse method was employed to determine the dynamic response of a soft, prospective biomimetic elastomer using Kolsky bar tests coupled with high-speed 3D digital image correlation. Individual tests were modeled using finite elements, and the dynamic stiffness of the elastomer was identified by matching the simulation results with test data using numerical optimization. Using this method, the average dynamic response was found to be nearly equivalent to the quasi-static response measured with stress-strain curves at compressive strains up to 60%, with an uncertainty of ±18%. Moreover, the behavior was consistent with the results in stress relaxation experiments and oscillatory tests although the latter were performed at lower strain levels.
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http://dx.doi.org/10.1016/j.jmbbm.2012.04.023 | DOI Listing |
Biofabrication
January 2025
Univ. Bordeaux, INSERM U1026 (BioTis), CHU Bordeaux, Université de Bordeaux Collège Sciences de la Santé, 146 Rue Léo Saignat, Bordeaux, 33000, FRANCE.
Producing oral soft tissues using tissue engineering could compensate for the disadvantages of autologous grafts (limited availability and increased patient morbidity) and currently available substitutes (shrinkage). However, there is a lack of in vitro-engineered oral tissues due to the difficulty of obtaining stable pre-vessels that connect to the host and enable graft success. The main objective was to assess the connection of pre-vascularised 3D-bioprinted gingival substitutes to the host vasculature when subcutaneously implanted in immunodeficient mice.
View Article and Find Full Text PDFInt J Pharm
January 2025
Nanostructure and Biomimetic Lab, Department of Nanotechnology, University of Kashmir, Hazratbal, Srinagar 190006, Jammu and Kashmir, India. Electronic address:
The second most prevalent cause of mortality among women is breast cancer, and paclitaxel (PTX) is an effective drug for its treatment. The present work aims to develop patch-based poly(ε-caprolactone) (PCL) nanofibers incorporating PTX as a localized and sustained drug delivery system. The co-deposition of poly(vinyl alcohol) (PVA) fibers during electrospinning was allowed to improve water absorption by the scaffold, which in turn facilitated the release of drug molecules.
View Article and Find Full Text PDFBr Med Bull
January 2025
Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
Introduction: Surgical treatment of pelvic girdle pain (PGP) involves arthrodesis of sacroiliac (SI) and pubic symphysis joints. Fusion of pubic symphysis involves the implantation of an autologous iliac crest tricortical graft harvested from the iliac crest. The objective was to assess the safety of a novel synthetic graft substitute (b.
View Article and Find Full Text PDFBioorg Chem
February 2025
Department of General Surgery, the Second Xiang-Ya Hospital, Central South University, Changsha 410011 China. Electronic address:
The transforming growth factor β (TGF-β) type 1 receptor (ALK5) plays a key role in tumor microenvironment. Small-molecule inhibitors of TGFβR1 provides a prospective approach for the treatment of malignant tumors. In this study, a series of 4-((3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)quinoline derivatives were identified as novel, potential TGFβR1 inhibitors.
View Article and Find Full Text PDFSmall
January 2025
Shanghai Key Laboratory of Advanced Polymeric Materials, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Endowing biomimetic sequence-controlled polymers with chiral functionality to construct stimuli-responsive chiral materials offers a promising approach for innovative chiroptical switch, but it remains challenging. Herein, it is reported that the self-assembly of sequence-defined chiral amphiphilic alternating azopeptoids to generate photo-responsive and ultrathin bilayer peptoidosomes with a vesicular thickness of ≈1.50 nm and a diameter of around ≈290 nm.
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